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Oxaliplatin Induced Digital Ischemia and Necrosis
المؤلفون المشاركون
Doganci, Suat
Kaya, Erkan
Kadan, Murat
Karabacak, Kubilay
Demirkilic, Ufuk
Durgun, Baris
Arslan, Gokhan
Bolcal, Cengiz
المصدر
Case Reports in Vascular Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-3، 3ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-05-04
دولة النشر
مصر
عدد الصفحات
3
التخصصات الرئيسية
الملخص EN
Introduction.
Digital ischemia is a rare complication of several chemotherapeutic medications.
We aimed to present a patient with digital ischemia, secondary to a new generation chemotherapeutic drug, oxaliplatin.
Case Report.
62-year-old woman presented to our department with severe pain, paresthesia, and distal acrocyanosis on her right hand fingertips.
Her complaints started five days after the third cycle of a chemotherapy protocol consisting of 5-fluorourasil (5-FU), folinic acid, and oxaliplatin due to advanced colon carcinoma.
On physical examination, hemorrhagic and partly ulcerative lesions were detected at her right hand fingertips.
Radial and ulnar pulses were absent at affected side.
Digital subtraction angiography revealed severe vascular resistance in the affected extremity.
Iloprost trometamol treatment was started with the dosage of 1 ng/kg/min.
In addition, low-molecule-weight heparin was used for preventing possible microemboli.
Symptomatic relief was provided after five days, and patient was discharged on 7th day of treatment.
Discussion.
The pathogenesis of oxaliplatin induced vascular toxicity remains unclear.
Endothelial damage, increased adherence of platelets, deposition of immune complexes as an immunologic effect of oxaliplatin, and hypercoagulable state may be the reason for arterial thrombosis, digital microemboli, possible digital ischemia, and their several consequences.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Karabacak, Kubilay& Kadan, Murat& Kaya, Erkan& Durgun, Baris& Arslan, Gokhan& Doganci, Suat…[et al.]. 2015. Oxaliplatin Induced Digital Ischemia and Necrosis. Case Reports in Vascular Medicine،Vol. 2015, no. 2015, pp.1-3.
https://search.emarefa.net/detail/BIM-1060304
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Karabacak, Kubilay…[et al.]. Oxaliplatin Induced Digital Ischemia and Necrosis. Case Reports in Vascular Medicine No. 2015 (2015), pp.1-3.
https://search.emarefa.net/detail/BIM-1060304
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Karabacak, Kubilay& Kadan, Murat& Kaya, Erkan& Durgun, Baris& Arslan, Gokhan& Doganci, Suat…[et al.]. Oxaliplatin Induced Digital Ischemia and Necrosis. Case Reports in Vascular Medicine. 2015. Vol. 2015, no. 2015, pp.1-3.
https://search.emarefa.net/detail/BIM-1060304
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1060304
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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