Effect of Extended-Release NiacinLaropiprant Combination on Plasma Adiponectin and Insulin Resistance in Chinese Patients with Dyslipidaemia
المؤلفون المشاركون
Yang, Ya-Ling
Masuda, Daisaku
Yamashita, Shizuya
Hu, Miao
Tomlinson, Brian
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-04-29
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Objectives.
This study examined whether the increase of adiponectin associated with extended-release (ER) niacin/laropiprant combination attenuates the adverse effect of niacin on glucose and insulin resistance in Hong Kong Chinese patients with dyslipidaemia.
Methods.
Patients ( N = 121 ) were treated with ER niacin/laropiprant 1 g/20 mg for 4 weeks and then the dose was doubled for an additional 8 weeks.
Measurements of fasting lipids, glucose, insulin, and adiponectin were performed at baseline and during the study.
Results.
There were significant ( P < 0.001 ) increases in glucose (9.4 ± 13.1%), insulin (70.2 ± 91.0%), HOMA-IR (87.8 ± 103.9%), and adiponectin (169.3 ± 111.6%).
The increase in adiponectin was significantly associated with increase in glucose ( r = 0.221 , P < 0.05 ) , insulin ( r = 0.184 , P < 0.05 ) , and HOMA-IR ( r = 0.237 , P < 0.01 ) and the association remained significant after adjustment for changes in body weight or body fat mass.
Conclusion.
Treatment with ER niacin/laropiprant led to a significant increase in adiponectin levels but worsening of glucose levels and insulin resistance, and the increase in adiponectin and insulin resistance were correlated suggesting the increase in adiponectin did not ameliorate the deterioration in insulin resistance.
Clinical trial is registered with number on WHO-ICTRP: ChiCTR-ONC-10001038.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hu, Miao& Yang, Ya-Ling& Masuda, Daisaku& Yamashita, Shizuya& Tomlinson, Brian. 2015. Effect of Extended-Release NiacinLaropiprant Combination on Plasma Adiponectin and Insulin Resistance in Chinese Patients with Dyslipidaemia. Disease Markers،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1060861
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hu, Miao…[et al.]. Effect of Extended-Release NiacinLaropiprant Combination on Plasma Adiponectin and Insulin Resistance in Chinese Patients with Dyslipidaemia. Disease Markers No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1060861
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hu, Miao& Yang, Ya-Ling& Masuda, Daisaku& Yamashita, Shizuya& Tomlinson, Brian. Effect of Extended-Release NiacinLaropiprant Combination on Plasma Adiponectin and Insulin Resistance in Chinese Patients with Dyslipidaemia. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1060861
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1060861
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر