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Assessment of Cell-Cycle Arrest Biomarkers to Predict Early and Delayed Acute Kidney Injury
المؤلفون المشاركون
Bell, Max
Larsson, Anders
Venge, Per
Bellomo, Rinaldo
Mårtensson, Johan
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-03-18
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Purpose.
To assess urinary tissue inhibitor of metalloproteinases-2 and insulin-like growth factor binding protein 7 ([TIMP-2]·[IGFBP7]), urinary neutrophil gelatinase-associated lipocalin (NGAL), and urinary cystatin-C as acute kidney injury predictors (AKI) exploring the association of nonrenal factors with elevated biomarker levels.
Methods.
We studied 94 patients with urine collected within 48 hours of ICU admission and no AKI at sampling.
AKI was defined by the Kidney Disease: Improving Global Outcomes criteria.
Predictive performance was assessed by the area under the receiver operating characteristics (ROC) curve.
Associations between biomarkers and clinical factors were assessed by multivariate linear regression.
Results.
Overall, 19 patients (20%) developed AKI within 48 hours.
[TIMP-2]·[IGFBP7], NGAL, or cystatin-C admission levels did not differ between patients without AKI and patients developing AKI.
[TIMP-2]·[IGFBP7], NGAL, and cystatin-C were poor AKI predictors (ROC areas 0.34–0.51).
Diabetes was independently associated with higher [TIMP-2]·[IGFBP7] levels ( P = 0.02 ) but AKI was not ( P = 0.24 ).
Sepsis was independently associated with higher NGAL ( P < 0.001 ) and cystatin-C ( P = 0.003 ) levels.
Conclusions.
Urinary [TIMP-2]·[IGFBP7], NGAL, and cystatin-C should be used cautiously as AKI predictors in general ICU patients since urine levels of these biomarkers are affected by factors other than AKI and their performance can be poor.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bell, Max& Larsson, Anders& Venge, Per& Bellomo, Rinaldo& Mårtensson, Johan. 2015. Assessment of Cell-Cycle Arrest Biomarkers to Predict Early and Delayed Acute Kidney Injury. Disease Markers،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1060864
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bell, Max…[et al.]. Assessment of Cell-Cycle Arrest Biomarkers to Predict Early and Delayed Acute Kidney Injury. Disease Markers No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1060864
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bell, Max& Larsson, Anders& Venge, Per& Bellomo, Rinaldo& Mårtensson, Johan. Assessment of Cell-Cycle Arrest Biomarkers to Predict Early and Delayed Acute Kidney Injury. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1060864
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1060864
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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