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The Relation between eNOS −786 CT, 4 ab, MMP-13 rs640198 GT, Eotaxin 426 CT, −384 AG, and 67 GA Polymorphisms and Long-Term Outcome in Patients with Coronary Artery Disease
المؤلفون المشاركون
Kincl, Vladimír
Máchal, Jan
Drozdová, Adéla
Panovský, Roman
Vasku, Anna
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-09-30
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Aim.
The purpose of this study is to determine the association between eotaxin 426 C/T, −384 A/G, 67 G/A, eNOS −786 T/C, 4 a/b, and MMP-13 rs640198 G/T and prognosis of patients with known CAD.
Methods.
From total of 1161 patients referred to coronary angiography, 532 patients with angiographically confirmed CAD were selected.
Their long-term outcome was followed up using hospital database.
Subsequent events were assessed in this study: death or combined endpoint-myocardial infarction, unstable angina pectoris, revascularization, heart failure hospitalization, and cardioverter-defibrillator implantation.
Results.
The multivariate Cox regression model identified age, smoking, and 3-vessel disease as significant predictors of all-cause death.
Further analysis showed that eotaxin 67 G/A (GA + AA versus GG) and eotaxin −384 A/G (GG versus GA + AA) were significant independent prognostic factors when added into the model: HR (95% CI) 2.81 (1.35–5.85), p=0.006; HR (95% CI) 2.63 (1.19–5.83), p=0.017; eotaxin −384 A/G was significantly associated with the event-free survival, but it did not provide the prognostic information above the effect of two- or three-vessel disease.
Conclusion.
The A allele in eotaxin 67 G/A polymorphism is associated with worse survival in CAD patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kincl, Vladimír& Máchal, Jan& Drozdová, Adéla& Panovský, Roman& Vasku, Anna. 2015. The Relation between eNOS −786 CT, 4 ab, MMP-13 rs640198 GT, Eotaxin 426 CT, −384 AG, and 67 GA Polymorphisms and Long-Term Outcome in Patients with Coronary Artery Disease. Disease Markers،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1060881
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kincl, Vladimír…[et al.]. The Relation between eNOS −786 CT, 4 ab, MMP-13 rs640198 GT, Eotaxin 426 CT, −384 AG, and 67 GA Polymorphisms and Long-Term Outcome in Patients with Coronary Artery Disease. Disease Markers No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1060881
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kincl, Vladimír& Máchal, Jan& Drozdová, Adéla& Panovský, Roman& Vasku, Anna. The Relation between eNOS −786 CT, 4 ab, MMP-13 rs640198 GT, Eotaxin 426 CT, −384 AG, and 67 GA Polymorphisms and Long-Term Outcome in Patients with Coronary Artery Disease. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1060881
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1060881
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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