The Relation between eNOS −786 CT, 4 ab, MMP-13 rs640198 GT, Eotaxin 426 CT, −384 AG, and 67 GA Polymorphisms and Long-Term Outcome in Patients with Coronary Artery Disease

الملخص EN

Aim.

The purpose of this study is to determine the association between eotaxin 426 C/T, −384 A/G, 67 G/A, eNOS −786 T/C, 4 a/b, and MMP-13 rs640198 G/T and prognosis of patients with known CAD.

Methods.

From total of 1161 patients referred to coronary angiography, 532 patients with angiographically confirmed CAD were selected.

Their long-term outcome was followed up using hospital database.

Subsequent events were assessed in this study: death or combined endpoint-myocardial infarction, unstable angina pectoris, revascularization, heart failure hospitalization, and cardioverter-defibrillator implantation.

Results.

The multivariate Cox regression model identified age, smoking, and 3-vessel disease as significant predictors of all-cause death.

Further analysis showed that eotaxin 67 G/A (GA + AA versus GG) and eotaxin −384 A/G (GG versus GA + AA) were significant independent prognostic factors when added into the model: HR (95% CI) 2.81 (1.35–5.85), p=0.006; HR (95% CI) 2.63 (1.19–5.83), p=0.017; eotaxin −384 A/G was significantly associated with the event-free survival, but it did not provide the prognostic information above the effect of two- or three-vessel disease.

Conclusion.

The A allele in eotaxin 67 G/A polymorphism is associated with worse survival in CAD patients.