Effects of Antitumor Necrosis Factor Therapy on Osteoprotegerin, Neopterin, and sRANKL Concentrations in Patients with Rheumatoid Arthritis

المؤلفون المشاركون

Fuchs, Dietmar
Kurz, Katharina
Herold, Manfred
Russe, Elisabeth
Klotz, Werner
Weiss, Guenter

المصدر

Disease Markers

العدد

المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-7، 7ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2015-10-21

دولة النشر

مصر

عدد الصفحات

7

التخصصات الرئيسية

الأمراض

الملخص EN

Background.

Rheumatoid arthritis is a systemic autoimmune disease characterized by joint erosions, progressive focal bone loss, and chronic inflammation.

Methods.

20 female patients with moderate-to-severe rheumatoid arthritis were treated with anti-TNF-antibody adalimumab in addition to concomitant antirheumatic therapies.

Patients were assessed for overall disease activity using the DAS28 score, and neopterin, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) concentrations as well as osteoprotegerin (OPG) and soluble receptor activator of NF-κB ligand (sRANKL) concentrations were determined before therapy and at week 12.

Neopterin as well as OPG and sRANKL were determined by commercial ELISAs.

Results.

Before anti-TNF therapy patients presented with high disease activity and elevated concentrations of circulating inflammatory markers.

OPG concentrations correlated with neopterin ( r s = 0.494 , p = 0 .

027 ), but not with DAS28.

OPG concentrations and disease activity scores declined during anti-TNF-treatment (both p < 0 .

02 ).

Patients who achieved remission ( n = 7 ) or showed a good response according to EULAR criteria ( n = 13 ) presented with initially higher baseline OPG levels, which subsequently decreased significantly during treatment ( p = 0 .

018 for remission, p = 0 .

011 for good response).

Conclusions.

Adalimumab therapy was effective in modifying disease activity and reducing proinflammatory and bone remodelling cascades.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Kurz, Katharina& Herold, Manfred& Russe, Elisabeth& Klotz, Werner& Weiss, Guenter& Fuchs, Dietmar. 2015. Effects of Antitumor Necrosis Factor Therapy on Osteoprotegerin, Neopterin, and sRANKL Concentrations in Patients with Rheumatoid Arthritis. Disease Markers،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1060892

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Kurz, Katharina…[et al.]. Effects of Antitumor Necrosis Factor Therapy on Osteoprotegerin, Neopterin, and sRANKL Concentrations in Patients with Rheumatoid Arthritis. Disease Markers No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1060892

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Kurz, Katharina& Herold, Manfred& Russe, Elisabeth& Klotz, Werner& Weiss, Guenter& Fuchs, Dietmar. Effects of Antitumor Necrosis Factor Therapy on Osteoprotegerin, Neopterin, and sRANKL Concentrations in Patients with Rheumatoid Arthritis. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1060892

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1060892