Serum Levels of Progranulin Are Closely Associated with Microvascular Complication in Type 2 Diabetes
المؤلفون المشاركون
Xu, Lin
Zhou, Bo
Li, Huixia
Liu, Jiali
Du, Junhui
Zang, Weijin
Wu, Shufang
Sun, Hongzhi
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-05-28
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Objective.
Progranulin (PGRN) was recently introduced as a novel marker of chronic inflammatory response in obesity and type 2 diabetes capable of directly affecting the insulin signaling pathway.
This study aimed to investigate the correlation between PGRN and type 2 diabetics with microvascular complications.
Methods.
PGRN serum levels and glucose metabolism related substance were measured in 84 type 2 diabetic patients with or without microangiopathies and 12 health persons.
Further analyses of serum PGRN in different stages of diabetic microangiopathies were conducted.
Results.
Serum levels of PGRN were markedly higher in type 2 diabetic patients with microangiopathies.
PGRN serum levels increased with the progress of diabetic microangiopathies with significantly highest values detectable in clinical diabetic nephropathy (CDN) and proliferative diabetic retinopathy (PDR) groups.
Serum PGRN concentrations in all individuals positively and markedly correlated with systolic blood pressure (SBP), diastolic blood pressure (DBP), body mass index (BMI), triglyceride (TG), urinary albumin excretion rate (UAER), blood urea nitrogen (BUN), creatinine (CRE), white blood cell (WBC), disease duration, IL-6, and TNF-α, while correlating negatively and significantly with eGFR.
Multiple linear regression analysis showed that only UAER and CRE were independently associated with serum PGRN.
Conclusion.
PGRN might be considered as a marker for diabetic microangiopathy and its severity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Xu, Lin& Zhou, Bo& Li, Huixia& Liu, Jiali& Du, Junhui& Zang, Weijin…[et al.]. 2015. Serum Levels of Progranulin Are Closely Associated with Microvascular Complication in Type 2 Diabetes. Disease Markers،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1060918
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Xu, Lin…[et al.]. Serum Levels of Progranulin Are Closely Associated with Microvascular Complication in Type 2 Diabetes. Disease Markers No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1060918
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Xu, Lin& Zhou, Bo& Li, Huixia& Liu, Jiali& Du, Junhui& Zang, Weijin…[et al.]. Serum Levels of Progranulin Are Closely Associated with Microvascular Complication in Type 2 Diabetes. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1060918
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1060918
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر