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The Relationship between Clinical Feature, Complex Immunophenotype, Chromosome Karyotype, and Outcome of Patients with Acute Myeloid Leukemia in China
المؤلفون المشاركون
Ding, Bingjie
Zhou, Lanlan
Li, Xiaodong
Zhong, Qingxiu
Yi, Zhengshan
Zheng, Zhongxin
Cao, Rui
Liao, Libin
Meng, Fanyi
Wang, Zhi-Xiang
Jiang, Xue-Jie
Yin, Chang-Xin
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-04-07
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Mixed phenotype acute leukemia (MPAL) is a complex entity expressing both lymphoid and myeloid immunophenotyping.
In the present study, 47 MPAL, 60 lymphoid antigen-positive acute myeloid leukemia (Ly+AML), and 90 acute myeloid leukemia with common myeloid immunophenotype (Ly−AML) patients were investigated.
We found that, in MPAL patients, there were high proportions of blast cells in bone marrow and incidence of hepatosplenomegaly, lymphadenopathy, and Philadelphia chromosome.
The overall survival (OS) and relapse-free survival (RFS) in MPAL patients were significantly shorter than those in Ly+AML and Ly−AML.
With regard to the patients with normal karyotype only, the OS and RFS of MPAL were significantly lower than those of the Ly+AML and Ly−AML; but there were no significant differences in OS and RFS among the patients with complex karyotype.
The OS rates of 3 groups with complex karyotype were lower than those of patients with normal karyotype.
In Cox multivariate analysis, complex karyotype was an independent pejorative factor for both OS and RFS.
Therefore, MPAL is confirmed to be a poor-risk disease while Ly+AML does not impact prognosis.
Complex karyotype is an unfavorable prognosis factor in AML patients with different immunophenotype.
Mixed immunophenotype and complex karyotype increase the adverse risk when they coexist.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ding, Bingjie& Zhou, Lanlan& Jiang, Xue-Jie& Li, Xiaodong& Zhong, Qingxiu& Wang, Zhi-Xiang…[et al.]. 2015. The Relationship between Clinical Feature, Complex Immunophenotype, Chromosome Karyotype, and Outcome of Patients with Acute Myeloid Leukemia in China. Disease Markers،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1060924
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ding, Bingjie…[et al.]. The Relationship between Clinical Feature, Complex Immunophenotype, Chromosome Karyotype, and Outcome of Patients with Acute Myeloid Leukemia in China. Disease Markers No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1060924
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ding, Bingjie& Zhou, Lanlan& Jiang, Xue-Jie& Li, Xiaodong& Zhong, Qingxiu& Wang, Zhi-Xiang…[et al.]. The Relationship between Clinical Feature, Complex Immunophenotype, Chromosome Karyotype, and Outcome of Patients with Acute Myeloid Leukemia in China. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1060924
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1060924
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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