Circulating MicroRNA-223 Serum Levels Do Not Predict Sepsis or Survival in Patients with Critical Illness
المؤلفون المشاركون
Koch, Alexander
Benz, Fabian
Tacke, Frank
Luedde, Mark
Trautwein, Christian
Roderburg, Christoph
Luedde, Tom
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-02-24
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Background and Aims.
Dysregulation of miR-223 was recently linked to various diseases associated with systemic inflammatory responses such as type 2 diabetes, cancer, and bacterial infections.
However, contradictory results are available on potential alterations of miR-223 serum levels during sepsis.
We thus aimed to evaluate the diagnostic and prognostic value of miR-223 serum concentrations in patients with critical illness and sepsis.
Methods.
We used i.v.
injection of lipopolysaccharide (LPS) as well as cecal pole ligation and puncture (CLP) for induction of polymicrobial sepsis in mice and measured alterations in serum levels of miR-223.
These results from mice were translated into a large and well-characterized cohort of critically ill patients admitted to the medical intensive care unit (ICU).
Finally, results from analysis in patients were correlated with clinical data and extensive sets of routine and experimental biomarkers.
Results.
Although LPS injection induced moderately elevated serum miR-223 levels in mice, no significant alterations in miR-223 serum levels were found in mice after CLP-induced sepsis.
In accordance with these results from animal models, serum miR-223 levels did not differ between critically ill patients and healthy controls.
However, ICU patients with more severe disease (APACHE-II score) showed moderately reduced circulating miR-223.
Strikingly, no differences in miR-223 levels were found in critically ill patients with or without sepsis, and serum levels of miR-223 did not correlate with classical markers of inflammation or bacterial infection.
Finally, low miR-223 serum levels were moderately associated with an unfavorable prognosis of patients during the ICU treatment but did not predict long-term mortality.
Conclusion.
Recent reports on alterations in miR-223 serum levels during sepsis revealed contradictory results, preventing a potential use of this miRNA in clinical routine.
We clearly show that miR-223 serum levels do not reflect the presence of sepsis neither in mouse models nor in a large cohort of ICU patients and do not indicate clinical outcome of critically ill patients.
Thus miR-223 serum levels should not be used as a biomarker in this setting.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Benz, Fabian& Tacke, Frank& Luedde, Mark& Trautwein, Christian& Luedde, Tom& Koch, Alexander…[et al.]. 2015. Circulating MicroRNA-223 Serum Levels Do Not Predict Sepsis or Survival in Patients with Critical Illness. Disease Markers،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1060930
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Benz, Fabian…[et al.]. Circulating MicroRNA-223 Serum Levels Do Not Predict Sepsis or Survival in Patients with Critical Illness. Disease Markers No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1060930
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Benz, Fabian& Tacke, Frank& Luedde, Mark& Trautwein, Christian& Luedde, Tom& Koch, Alexander…[et al.]. Circulating MicroRNA-223 Serum Levels Do Not Predict Sepsis or Survival in Patients with Critical Illness. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1060930
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1060930
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر