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The Value of Circulating Nogo-B for Evaluating Hepatic Functional Reserve in Patients with Cirrhosis
المؤلفون المشاركون
Wen, Maoyao
Men, Ruoting
Yang, Zongze
Dan, Xuelian
Wu, Wenchao
Liu, Xiaojing
Yang, Li
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-05-06
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Objective.
To examine Nogo-B in liver tissues and plasma of patients with liver cirrhosis and associate them with various clinical parameters.
Materials and Methods.
Nogo-B protein expression was examined by immunohistochemistry in 24 human fibrotic/cirrhotic liver specimens and 10 healthy controls.
We determined plasma Nogo-B levels by enzyme-linked immunosorbent assay in 301 patients with liver cirrhosis and 153 healthy controls, and then analyzed various clinical parameters.
Results.
Nogo-B was mainly expressed in nonparenchymal cells in the liver and was marked increased in liver with significant fibrosis/cirrhosis compared to controls.
Moreover, Metavir F4 showed a higher level of expression than F2.
Plasma Nogo-B levels were significantly higher in cirrhotic patients than in healthy controls and were the highest in Child-Pugh class C patients.
Plasma Nogo-B levels were positively correlated with Child-Pugh scores.
However, there was no relationship between plasma Nogo-B levels and etiology of liver diseases, ALT, AST, platelet counts, and the severity of esophagogastric varices.
Conclusions.
Nogo-B is mainly expressed in hepatic nonparenchymal cells and is present in plasma.
Abnormally high plasma levels of Nogo-B are associated with hepatic cirrhosis and Child-Pugh score, but not correlated with the grade of liver inflammation or portal hypertension.
Plasma Nogo-B may be a novel surrogate marker to reflect liver function reserve.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wen, Maoyao& Men, Ruoting& Yang, Zongze& Dan, Xuelian& Wu, Wenchao& Liu, Xiaojing…[et al.]. 2015. The Value of Circulating Nogo-B for Evaluating Hepatic Functional Reserve in Patients with Cirrhosis. Disease Markers،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1060938
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wen, Maoyao…[et al.]. The Value of Circulating Nogo-B for Evaluating Hepatic Functional Reserve in Patients with Cirrhosis. Disease Markers No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1060938
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wen, Maoyao& Men, Ruoting& Yang, Zongze& Dan, Xuelian& Wu, Wenchao& Liu, Xiaojing…[et al.]. The Value of Circulating Nogo-B for Evaluating Hepatic Functional Reserve in Patients with Cirrhosis. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1060938
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1060938
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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