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Macrophage Migration Inhibitory Factor Promoter Polymorphisms (−794 CATT5–8 and −173 G>C): Relationship with mRNA Expression and Soluble MIF Levels in Young Obese Subjects
المؤلفون المشاركون
Parra-Rojas, Isela
Matia-García, Inés
García-Arellano, Samuel
Hernández-Bello, Jorge
Salgado-Goytia, Lorenzo
Muñoz-Valle, José Francisco
Salgado-Bernabé, Aralia B.
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-04-20
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
We analyzed the relationship of −794 CATT5–8 and −173 G>C MIF polymorphisms with mRNA and soluble MIF in young obese subjects.
A total of 250 young subjects, 150 normal-weight and 100 obese subjects, were recruited in the study.
Genotyping of −794 CATT5–8 and −173 G>C MIF polymorphisms was performed by PCR and PCR-RFLP, respectively.
MIF mRNA expression was determined by real-time PCR and serum MIF levels were measured using an ELISA kit.
For both MIF promoter polymorphisms, no significant differences in the genotype and allele frequencies between groups were observed.
MIF mRNA expression was slightly higher in obese subjects than in normal-weight subjects (1.38-fold), while soluble MIF levels did not show differences between groups.
In addition, we found an increase in MIF mRNA expression in carriers of the 6,6 and C/C genotypes and the 6G haplotype of the −794 CATT5–8 and −173 G>C MIF polymorphisms, although it was not significant.
In conclusion, this study found no relationship between obesity and MIF gene promoter polymorphisms with MIF mRNA expression in young obese subjects.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Matia-García, Inés& Salgado-Goytia, Lorenzo& Muñoz-Valle, José Francisco& García-Arellano, Samuel& Hernández-Bello, Jorge& Salgado-Bernabé, Aralia B.…[et al.]. 2015. Macrophage Migration Inhibitory Factor Promoter Polymorphisms (−794 CATT5–8 and −173 G>C): Relationship with mRNA Expression and Soluble MIF Levels in Young Obese Subjects. Disease Markers،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1060950
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Matia-García, Inés…[et al.]. Macrophage Migration Inhibitory Factor Promoter Polymorphisms (−794 CATT5–8 and −173 G>C): Relationship with mRNA Expression and Soluble MIF Levels in Young Obese Subjects. Disease Markers No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1060950
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Matia-García, Inés& Salgado-Goytia, Lorenzo& Muñoz-Valle, José Francisco& García-Arellano, Samuel& Hernández-Bello, Jorge& Salgado-Bernabé, Aralia B.…[et al.]. Macrophage Migration Inhibitory Factor Promoter Polymorphisms (−794 CATT5–8 and −173 G>C): Relationship with mRNA Expression and Soluble MIF Levels in Young Obese Subjects. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1060950
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1060950
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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