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Site-Specific Secretome Map Evidences VSMC-Related Markers of Coronary Atherosclerosis Grade and Extent in the Hypercholesterolemic Swine
المؤلفون المشاركون
Parodi, Oberdan
Rocchiccioli, Silvia
Cecchettini, Antonella
Ucciferri, Nadia
Terreni, Marianna
Viglione, Federica
Citti, Lorenzo
Pelosi, Gualtiero
Trivella, M. G.
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-08-25
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
A major drawback in coronary atherosclerosis (ATS) research is the difficulty of investigating early phase of plaque growth and related features in the clinical context.
In this study, secreted proteins from atherosclerotic coronary arteries in a hypercholesterolemic swine model were characterized by a proteomics approach and their expression was correlated to site-specific ATS stage and extent.
A wide coronary artery map of secreted proteins has been obtained in high fat (HF) diet induced ATS swine model and a significantly different expression of many proteins related to vascular smooth muscle cell (VSMC) activation/migration has been identified.
Significant associations with ATS stage of HF coronary lesions were found for several VSMC-derived proteins and validated for chitinase 3 like protein 1 (CHI3L1) by tissue immunoexpression.
A direct correlation R2=0.85 was evidenced with intima to media thickness ratio values and ELISA confirmed the higher blood concentrations of CHI3L1 in HF cases.
These findings confirmed the pivotal role of VSMCs in coronary plaque development and demonstrated a strong site-specific relation between VSMC-secreted CHI3L1 and lesion grade, suggesting that this protein could be proposed as a useful biomarker for diagnosing and staging of atherosclerotic lesions in coronary artery disease.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Rocchiccioli, Silvia& Cecchettini, Antonella& Ucciferri, Nadia& Terreni, Marianna& Viglione, Federica& Trivella, M. G.…[et al.]. 2015. Site-Specific Secretome Map Evidences VSMC-Related Markers of Coronary Atherosclerosis Grade and Extent in the Hypercholesterolemic Swine. Disease Markers،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1060951
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Rocchiccioli, Silvia…[et al.]. Site-Specific Secretome Map Evidences VSMC-Related Markers of Coronary Atherosclerosis Grade and Extent in the Hypercholesterolemic Swine. Disease Markers No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1060951
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Rocchiccioli, Silvia& Cecchettini, Antonella& Ucciferri, Nadia& Terreni, Marianna& Viglione, Federica& Trivella, M. G.…[et al.]. Site-Specific Secretome Map Evidences VSMC-Related Markers of Coronary Atherosclerosis Grade and Extent in the Hypercholesterolemic Swine. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1060951
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1060951
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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