Serum MicroRNA Profiles Serve as Novel Biomarkers for the Diagnosis of Alzheimer’s Disease
المؤلفون المشاركون
Li, Donghai
Wang, Cheng
Dong, Hui
Li, Jialu
Huang, Lei
Chen, Xi
Wang, Tao
Hu, Caiyou
Xu, Jun
Zhang, Chunni
Zen, Ke
Xiao, Shifu
Yan, Qiao
Zhang, Chen-Yu
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-05-20
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Alzheimer’s disease (AD) is the most common type of dementia, and promptly diagnosis of AD is crucial for delaying the development of disease and improving patient quality of life.
However, AD detection, particularly in the early stages, remains a substantial challenge due to the lack of specific biomarkers.
The present study was undertaken to identify and validate the potential of circulating miRNAs as novel biomarkers for AD.
Solexa sequencing was employed to screen the expression profile of serum miRNAs in AD and controls.
RT-qPCR was used to confirm the altered miRNAs at the individual level.
Moreover, candidate miRNAs were examined in the serum samples of patients with mild cognitive impairment (MCI) and vascular dementia (VD).
The results showed that four miRNAs (miR-31, miR-93, miR-143, and miR-146a) were markedly decreased in AD patients’ serum compared with controls.
Receiver operating characteristic curve analysis demonstrated that this panel of four miRNAs could be used as potential biomarker for AD.
Furthermore, miR-93, and miR-146a were significantly elevated in MCI compared with controls, and the panel of miR-31, miR-93 and miR-146a can be used to discriminate AD from VD.
We established a panel of four serum miRNAs as a novel noninvasive biomarker for AD diagnosis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Dong, Hui& Li, Jialu& Huang, Lei& Chen, Xi& Li, Donghai& Wang, Tao…[et al.]. 2015. Serum MicroRNA Profiles Serve as Novel Biomarkers for the Diagnosis of Alzheimer’s Disease. Disease Markers،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1060995
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Dong, Hui…[et al.]. Serum MicroRNA Profiles Serve as Novel Biomarkers for the Diagnosis of Alzheimer’s Disease. Disease Markers No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1060995
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Dong, Hui& Li, Jialu& Huang, Lei& Chen, Xi& Li, Donghai& Wang, Tao…[et al.]. Serum MicroRNA Profiles Serve as Novel Biomarkers for the Diagnosis of Alzheimer’s Disease. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1060995
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1060995
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر