Significant Association of HLA-B Alleles and Genotypes in Thai Children with Autism Spectrum Disorders: A Case-Control Study
المؤلفون المشاركون
Puangpetch, Apichaya
Suwannarat, Pongwut
Chamnanphol, Montri
Koomdee, Napatrupron
Ngamsamut, Nattawat
Limsila, Penkhae
Sukasem, Chonlaphat
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-12-24
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Autism is a severe neurodevelopmental disorder.
Many susceptible causative genes have been identified.
Most of the previous reports showed the relationship between the Human Leukocyte Antigen (HLA) gene and etiology of autism.
In order to identify HLA-B alleles associated with autism in Thai population, we compared the frequency of HLA-B allele in 364 autistic subjects with 952 normal subjects by using a two-stage sequence-specific oligonucleotide probe system (PCR-SSOP) method based on flow-cytometry technology.
HLA-B⁎13:02 (P=0.019, OR = 2.229), HLA-B⁎38:02 (P=0.049, OR = 1.628), HLA-B⁎44:03 (P=0.016, OR = 1.645), and HLA-B⁎56:01 (P = 1.78 × 10−4, OR = 4.927) alleles were significantly increased in autistic subjects compared with normal subjects.
Moreover, we found that the HLA-B⁎18:02 (P=0.016, OR = 0.375) and HLA-B⁎46:12 (P=0.008, OR = 0.147) alleles were negatively associated with autism when compared to normal controls.
Both alleles might have a protective role in disease development.
In addition, four HLA-B genotypes of autistic patients had statistically significant relationship with control groups, consisting of HLA-B⁎3905/⁎5801 (P=0.032, OR = 24.697), HLA-B⁎2704/⁎5801 (P=0.022, OR = 6.872), HLA-B⁎3501/⁎4403 (P=0.021, OR = 30.269), and HLA-B⁎1801/⁎4402 (P = 0.017, OR = 13.757).
This is the first report on HLA-B associated with Thai autism and may serve as a marker for genetic susceptibility to autism in Thai population.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Puangpetch, Apichaya& Suwannarat, Pongwut& Chamnanphol, Montri& Koomdee, Napatrupron& Ngamsamut, Nattawat& Limsila, Penkhae…[et al.]. 2015. Significant Association of HLA-B Alleles and Genotypes in Thai Children with Autism Spectrum Disorders: A Case-Control Study. Disease Markers،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1061020
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Puangpetch, Apichaya…[et al.]. Significant Association of HLA-B Alleles and Genotypes in Thai Children with Autism Spectrum Disorders: A Case-Control Study. Disease Markers No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1061020
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Puangpetch, Apichaya& Suwannarat, Pongwut& Chamnanphol, Montri& Koomdee, Napatrupron& Ngamsamut, Nattawat& Limsila, Penkhae…[et al.]. Significant Association of HLA-B Alleles and Genotypes in Thai Children with Autism Spectrum Disorders: A Case-Control Study. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1061020
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1061020
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر