![](/images/graphics-bg.png)
DNA Repair Gene Polymorphism and the Risk of Mitral Chordae Tendineae Rupture
المؤلفون المشاركون
Vatan, Mehmet Bulent
Kalayci Yigin, Aysel
Akdemir, Ramazan
Necati Murat Aksoy, Muhammed
Cakar, Mehmet Akif
Kilic, Harun
Karacan, Keziban
Kaleli, Suleyman
Erkorkmaz, Unal
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-10-28
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Polymorphisms in Lys939Gln XPC gene may diminish DNA repair capacity, eventually increasing the risk of carcinogenesis.
The aim of the present study was to evaluate the significance of polymorphism Lys939Gln in XPC gene in patients with mitral chordae tendinea rupture (MCTR).
Twenty-one patients with MCTR and thirty-seven age and sex matched controls were enrolled in the study.
Genotyping of XPC gene Lys939Gln polymorphism was carried out using polymerase chain reaction- (PCR-) restriction fragment length polymorphism (RFLP).
The frequencies of the heterozygote genotype (Lys/Gln-AC) and homozygote genotype (Gln/Gln-CC) were significantly different in MCTR as compared to control group, respectively (52.4% versus 43.2%, p=0.049; 38.15% versus 16.2%, p=0.018).
Homozygote variant (Gln/Gln) genotype was significantly associated with increased risk of MCTR (OR = 2.059; 95% CI: 1.097–3.863; p=0.018).
Heterozygote variant (Lys/Gln) genotype was also highly significantly associated with increased risk of MCTR (OR = 1.489; 95% CI: 1.041–2.129; p=0.049).
The variant allele C was found to be significantly associated with MCTR (OR = 1.481; 95% CI: 1.101–1.992; p=0.011).
This study has demonstrated the association of XPC gene Lys939Gln polymorphism with MCTR, which is significantly associated with increased risk of MCTR.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kalayci Yigin, Aysel& Vatan, Mehmet Bulent& Akdemir, Ramazan& Necati Murat Aksoy, Muhammed& Cakar, Mehmet Akif& Kilic, Harun…[et al.]. 2015. DNA Repair Gene Polymorphism and the Risk of Mitral Chordae Tendineae Rupture. Disease Markers،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1061053
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kalayci Yigin, Aysel…[et al.]. DNA Repair Gene Polymorphism and the Risk of Mitral Chordae Tendineae Rupture. Disease Markers No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1061053
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kalayci Yigin, Aysel& Vatan, Mehmet Bulent& Akdemir, Ramazan& Necati Murat Aksoy, Muhammed& Cakar, Mehmet Akif& Kilic, Harun…[et al.]. DNA Repair Gene Polymorphism and the Risk of Mitral Chordae Tendineae Rupture. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1061053
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1061053
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)