Aldehyde Dehydrogenase Polymorphisms and Blood Pressure Elevation in the Japanese: A Cross-Sectional and a Longitudinal Study over 20 Years in the Shimane CoHRE Study
المؤلفون المشاركون
Isomura, Minoru
Wang, Tao
Yamasaki, Masayuki
Hasan, Md. Zahid
Shiwaku, Kuninori
Nabika, Toru
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-4، 4ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-06-22
دولة النشر
مصر
عدد الصفحات
4
التخصصات الرئيسية
الملخص EN
Purpose.
Effects of a genetic polymorphism in the aldehyde dehydrogenase-2 (ALDH2) on blood pressure (BP) were investigated in a cross-sectional and a longitudinal study over 20 years on Japanese rural residents.
Methods.
Health examinations were held through 2006 to 2012, and 3,202 participates were recruited for this study.
Among these participants, 560 individuals had medical records that were obtained in a health examination 20 years ago.
Genomic DNA of participants was extracted from blood and the genotype of a polymorphism in ALDH2 was determined by the TaqMan method.
Multivariate regression analyses were performed to examine association between BP and the genetic polymorphism in the ALDH2 gene.
Results.
Systolic and diastolic BP were higher in the ALDH2∗1/∗1 than the others (ALDH2∗1/∗2 or ALDH2∗2/∗2).
Genetic variation of the ALDH2 gene apparently influenced drinking behavior as the number of the drinkers was significantly reduced in the ALDH2∗2/∗2 after 20 years of the observation period.
This polymorphism, however, did not confer a risk for BP increase in the longitudinal observation.
Conclusion.
The present cross-sectional study confirmed a genetic effect of the ALDH2 gene on BP.
In contrast, no significant effects on BP were identified in a longitudinal study, which may require a careful consideration.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Isomura, Minoru& Wang, Tao& Yamasaki, Masayuki& Hasan, Md. Zahid& Shiwaku, Kuninori& Nabika, Toru. 2015. Aldehyde Dehydrogenase Polymorphisms and Blood Pressure Elevation in the Japanese: A Cross-Sectional and a Longitudinal Study over 20 Years in the Shimane CoHRE Study. Disease Markers،Vol. 2015, no. 2015, pp.1-4.
https://search.emarefa.net/detail/BIM-1061054
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Isomura, Minoru…[et al.]. Aldehyde Dehydrogenase Polymorphisms and Blood Pressure Elevation in the Japanese: A Cross-Sectional and a Longitudinal Study over 20 Years in the Shimane CoHRE Study. Disease Markers No. 2015 (2015), pp.1-4.
https://search.emarefa.net/detail/BIM-1061054
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Isomura, Minoru& Wang, Tao& Yamasaki, Masayuki& Hasan, Md. Zahid& Shiwaku, Kuninori& Nabika, Toru. Aldehyde Dehydrogenase Polymorphisms and Blood Pressure Elevation in the Japanese: A Cross-Sectional and a Longitudinal Study over 20 Years in the Shimane CoHRE Study. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-4.
https://search.emarefa.net/detail/BIM-1061054
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1061054
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر