![](/images/graphics-bg.png)
Aerobic Glycolysis as a Marker of Tumor Aggressiveness: Preliminary Data in High Grade Human Brain Tumors
المؤلفون المشاركون
Huang, Jiayi
Vlassenko, Andrei G.
McConathy, Jonathan
Couture, Lars E.
Su, Yi
Massoumzadeh, Parinaz
Leeds, Hayden S.
Chicoine, Michael R.
Tran, David D.
Dahiya, Sonika
Marcus, Daniel S.
Fouke, Sarah Jost
Rich, Keith M.
Raichle, Marcus E.
Benzinger, Tammie L. S.
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-09-03
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Objectives.
Glucose metabolism outside of oxidative phosphorylation, or aerobic glycolysis (AG), is a hallmark of active cancer cells that is not directly measured with standard 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET).
In this study, we characterized tumor regions with elevated AG defined based on PET measurements of glucose and oxygen metabolism.
Methods.
Fourteen individuals with high-grade brain tumors underwent structural MR scans and PET measurements of cerebral blood flow (CBF), oxygen (CMRO2) and glucose (CMRGlu) metabolism, and AG, using 15O-labeled CO, O2 and H2O, and FDG, and were compared to a normative cohort of 20 age-matched individuals.
Results.
Elevated AG was observed in most high-grade brain tumors and it was associated with decreased CMRO2 and CBF, but not with significant changes in CMRGlu.
Elevated AG was a dramatic and early sign of tumor growth associated with decreased survival.
AG changes associated with tumor growth were differentiated from the effects of nonneoplastic processes such as epileptic seizures.
Conclusions.
Our findings demonstrate that high-grade brain tumors exhibit elevated AG as a marker of tumor growth and aggressiveness.
AG may detect areas of active tumor growth that are not evident on conventional FDG PET.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Vlassenko, Andrei G.& McConathy, Jonathan& Couture, Lars E.& Su, Yi& Massoumzadeh, Parinaz& Leeds, Hayden S.…[et al.]. 2015. Aerobic Glycolysis as a Marker of Tumor Aggressiveness: Preliminary Data in High Grade Human Brain Tumors. Disease Markers،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1061073
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Vlassenko, Andrei G.…[et al.]. Aerobic Glycolysis as a Marker of Tumor Aggressiveness: Preliminary Data in High Grade Human Brain Tumors. Disease Markers No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1061073
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Vlassenko, Andrei G.& McConathy, Jonathan& Couture, Lars E.& Su, Yi& Massoumzadeh, Parinaz& Leeds, Hayden S.…[et al.]. Aerobic Glycolysis as a Marker of Tumor Aggressiveness: Preliminary Data in High Grade Human Brain Tumors. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1061073
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1061073
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)