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High-Dose versus Low-Dose Vitamin D Supplementation and Arterial Stiffness among Individuals with Prehypertension and Vitamin D Deficiency
المؤلفون المشاركون
Zaleski, Amanda L.
Panza, Gregory
Swales, Heather
Arora, Pankaj
Newton-Cheh, Christopher
Wang, Thomas
Thompson, Paul D.
Parker, Beth A.
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-09-16
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Introduction.
Vitamin D deficiency is associated with the onset and progression of hypertension and cardiovascular disease (CVD).
However, mechanisms underlying vitamin D deficiency-mediated increased risk of CVD remain unknown.
We sought to examine the differential effect of high-dose versus low-dose vitamin D supplementation on markers of arterial stiffness among ~40 vitamin D deficient adults with prehypertension.
Methods.
Participants were randomized to high-dose (4000 IU/d) versus low-dose (400 IU/d) oral vitamin D3 for 6 months.
24 hr ambulatory blood pressure (BP), carotid-femoral pulse wave velocity, and pulse wave analyses were obtained at baseline and after 6 months of vitamin D supplementation.
Results.
There were no changes in resting BP or pulse wave velocity over 6 mo regardless of vitamin D dose (all p > 0.202 ).
High-dose vitamin D decreased augmentation index and pressure by 12.3 ± 5.3% ( p = 0.047 ) and 4.0 ± 1.5 mmHg ( p = 0.02 ), respectively.
However, these decreases in arterial stiffness were not associated with increases in serum 25-hydroxyvitamin D over 6 mo ( p = 0.425 ).
Conclusion.
High-dose vitamin D supplementation appears to lower surrogate measures of arterial stiffness but not indices of central pulse wave velocity.
Clinical Trial Registration.
This trial is registered with www.clinicaltrials.gov (Unique Identifier: NCT01240512).
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zaleski, Amanda L.& Panza, Gregory& Swales, Heather& Arora, Pankaj& Newton-Cheh, Christopher& Wang, Thomas…[et al.]. 2015. High-Dose versus Low-Dose Vitamin D Supplementation and Arterial Stiffness among Individuals with Prehypertension and Vitamin D Deficiency. Disease Markers،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1061080
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zaleski, Amanda L.…[et al.]. High-Dose versus Low-Dose Vitamin D Supplementation and Arterial Stiffness among Individuals with Prehypertension and Vitamin D Deficiency. Disease Markers No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1061080
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zaleski, Amanda L.& Panza, Gregory& Swales, Heather& Arora, Pankaj& Newton-Cheh, Christopher& Wang, Thomas…[et al.]. High-Dose versus Low-Dose Vitamin D Supplementation and Arterial Stiffness among Individuals with Prehypertension and Vitamin D Deficiency. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1061080
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1061080
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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