Prognostic Role of MicroRNA-200c-141 Cluster in Various Human Solid Malignant Neoplasms
المؤلفون المشاركون
Xiao, Tao
Bu, Jie
Li, Xiao-yang
Liu, Li-hong
Li, Hui
Xiong, Liang
Guo, Hong-bin
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-19، 19ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-10-18
دولة النشر
مصر
عدد الصفحات
19
التخصصات الرئيسية
الملخص EN
The miR-200 family has emerged recently as a noticeable marker for predicting cancer prognosis and tumor progression.
We aimed to review the evidence of miR-200c-141 genomic cluster as prognostic biomarkers in cancers.
The results suggested that high level of miR-200c had no significant impact on OS (HR = 1.14 [0.77–1.69], P=0.501) and DFS/PFS (HR = 0.72 [0.45–1.14], P=0.161).
Stratified analyses revealed that high miR-200c expression was significantly related to poor OS in serum/plasma (HR = 2.12 [1.62–2.77], P=0.000) but not in tissues (HR = 0.89 [0.58–1.37], P=0.599).
High miR-200c expression was significantly associated with favorable DFS/PFS in tissues (HR = 0.56 [0.43–0.73], P=0.000) but worse DFS/PFS in serum/plasma (HR = 1.90 [1.08–3.36], P=0.027).
For miR-141, we found that high miR-141 expression predicted no significant impact on OS (HR = 1.18 [0.74–1.88], P=0.482) but poor DFS/PFS (HR = 1.11 [1.04–1.20], P=0.003).
Similarly, subgroup analyses showed that high miR-141 expression predicted poor OS in serum/plasma (HR = 4.34 [2.30–8.21], P=0.000) but not in tissues (HR = 1.00 [0.92–1.09], P=0.093).
High miR-141 expression was significantly associated with worse DFS/PFS in tissues (HR = 1.12 [1.04–1.20], P=0.002) but not in serum/plasma (HR = 0.90 [0.44–1.83], P=0.771).
Our findings indicated that, compared to their tissue counterparts, the expression level of miR-200c and miR-141 in peripheral blood may be more effective for monitoring cancer prognosis.
High miR-141 expression was better at predicting tumor progression than survival for malignant tumors.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Xiao-yang& Li, Hui& Bu, Jie& Xiong, Liang& Guo, Hong-bin& Liu, Li-hong…[et al.]. 2015. Prognostic Role of MicroRNA-200c-141 Cluster in Various Human Solid Malignant Neoplasms. Disease Markers،Vol. 2015, no. 2015, pp.1-19.
https://search.emarefa.net/detail/BIM-1061081
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Xiao-yang…[et al.]. Prognostic Role of MicroRNA-200c-141 Cluster in Various Human Solid Malignant Neoplasms. Disease Markers No. 2015 (2015), pp.1-19.
https://search.emarefa.net/detail/BIM-1061081
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Xiao-yang& Li, Hui& Bu, Jie& Xiong, Liang& Guo, Hong-bin& Liu, Li-hong…[et al.]. Prognostic Role of MicroRNA-200c-141 Cluster in Various Human Solid Malignant Neoplasms. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-19.
https://search.emarefa.net/detail/BIM-1061081
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1061081
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر