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Prognostic Role of MicroRNA-200c-141 Cluster in Various Human Solid Malignant Neoplasms
المؤلفون المشاركون
Xiao, Tao
Bu, Jie
Li, Xiao-yang
Liu, Li-hong
Li, Hui
Xiong, Liang
Guo, Hong-bin
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-19، 19ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-10-18
دولة النشر
مصر
عدد الصفحات
19
التخصصات الرئيسية
الملخص EN
The miR-200 family has emerged recently as a noticeable marker for predicting cancer prognosis and tumor progression.
We aimed to review the evidence of miR-200c-141 genomic cluster as prognostic biomarkers in cancers.
The results suggested that high level of miR-200c had no significant impact on OS (HR = 1.14 [0.77–1.69], P=0.501) and DFS/PFS (HR = 0.72 [0.45–1.14], P=0.161).
Stratified analyses revealed that high miR-200c expression was significantly related to poor OS in serum/plasma (HR = 2.12 [1.62–2.77], P=0.000) but not in tissues (HR = 0.89 [0.58–1.37], P=0.599).
High miR-200c expression was significantly associated with favorable DFS/PFS in tissues (HR = 0.56 [0.43–0.73], P=0.000) but worse DFS/PFS in serum/plasma (HR = 1.90 [1.08–3.36], P=0.027).
For miR-141, we found that high miR-141 expression predicted no significant impact on OS (HR = 1.18 [0.74–1.88], P=0.482) but poor DFS/PFS (HR = 1.11 [1.04–1.20], P=0.003).
Similarly, subgroup analyses showed that high miR-141 expression predicted poor OS in serum/plasma (HR = 4.34 [2.30–8.21], P=0.000) but not in tissues (HR = 1.00 [0.92–1.09], P=0.093).
High miR-141 expression was significantly associated with worse DFS/PFS in tissues (HR = 1.12 [1.04–1.20], P=0.002) but not in serum/plasma (HR = 0.90 [0.44–1.83], P=0.771).
Our findings indicated that, compared to their tissue counterparts, the expression level of miR-200c and miR-141 in peripheral blood may be more effective for monitoring cancer prognosis.
High miR-141 expression was better at predicting tumor progression than survival for malignant tumors.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Xiao-yang& Li, Hui& Bu, Jie& Xiong, Liang& Guo, Hong-bin& Liu, Li-hong…[et al.]. 2015. Prognostic Role of MicroRNA-200c-141 Cluster in Various Human Solid Malignant Neoplasms. Disease Markers،Vol. 2015, no. 2015, pp.1-19.
https://search.emarefa.net/detail/BIM-1061081
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Xiao-yang…[et al.]. Prognostic Role of MicroRNA-200c-141 Cluster in Various Human Solid Malignant Neoplasms. Disease Markers No. 2015 (2015), pp.1-19.
https://search.emarefa.net/detail/BIM-1061081
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Xiao-yang& Li, Hui& Bu, Jie& Xiong, Liang& Guo, Hong-bin& Liu, Li-hong…[et al.]. Prognostic Role of MicroRNA-200c-141 Cluster in Various Human Solid Malignant Neoplasms. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-19.
https://search.emarefa.net/detail/BIM-1061081
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1061081
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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