Genome-Wide Scan for Methylation Profiles in Keloids
المؤلفون المشاركون
Worsham, Maria J.
Jones, Lamont R.
Young, William
Divine, George
Datta, Indrani
Ozog, David
Chen, Kang Mei
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-05-14
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Keloids are benign fibroproliferative tumors of the skin which commonly occur after injury mainly in darker skinned patients.
Medical treatment is fraught with high recurrence rates mainly because of an incomplete understanding of the biological mechanisms that lead to keloids.
The purpose of this project was to examine keloid pathogenesis from the epigenome perspective of DNA methylation.
Genome-wide profiling used the Infinium HumanMethylation450 BeadChip to interrogate DNA from 6 fresh keloid and 6 normal skin samples from 12 anonymous donors.
A 3-tiered approach was used to call out genes most differentially methylated between keloid and normal.
When compared to normal, of the 685 differentially methylated CpGs at Tier 3, 510 were hypomethylated and 175 were hypermethylated with 190 CpGs in promoter and 495 in nonpromoter regions.
The 190 promoter region CpGs corresponded to 152 genes: 96 (63%) were hypomethylated and 56 (37%) hypermethylated.
This exploratory genome-wide scan of the keloid methylome highlights a predominance of hypomethylated genomic landscapes, favoring nonpromoter regions.
DNA methylation, as an additional mechanism for gene regulation in keloid pathogenesis, holds potential for novel treatments that reverse deleterious epigenetic changes.
As an alternative mechanism for regulating genes, epigenetics may explain why gene mutations alone do not provide definitive mechanisms for keloid formation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jones, Lamont R.& Young, William& Divine, George& Datta, Indrani& Chen, Kang Mei& Ozog, David…[et al.]. 2015. Genome-Wide Scan for Methylation Profiles in Keloids. Disease Markers،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1061083
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jones, Lamont R.…[et al.]. Genome-Wide Scan for Methylation Profiles in Keloids. Disease Markers No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1061083
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jones, Lamont R.& Young, William& Divine, George& Datta, Indrani& Chen, Kang Mei& Ozog, David…[et al.]. Genome-Wide Scan for Methylation Profiles in Keloids. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1061083
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1061083
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر