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Effect of Narrow-Band Ultraviolet B Phototherapy and Methotrexate on MicroRNA (146a) Levels in Blood of Psoriatic Patients
المؤلفون المشاركون
Ele-Refaei, Asmaa M.
El-Esawy, Fatma
المصدر
Dermatology Research and Practice
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-10-29
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Background.
Recently, some miRNAs have been proven to show aberrant expression in psoriasis and play a role in the pathogenesis of the disease.
Objective.
To find out whether NB-UVB or methotrexate treatment affects whole blood levels of human miRNA (146a) in patients with psoriasis and demonstrate its correlation with disease severity.
Methods.
Blood samples were obtained from healthy control and from psoriatic patients before and 12 weeks after treatment with NB-UVB, methotrexate.
Quantification of human miRNA (146a) by Real Time PCR (RT-PCR).
Results.
Blood human miRNA (146a) levels were higher in patients with psoriasis than those in healthy controls ( P = 0.001 ); it had no significant positive relation with PASI scores in patients ( r = 0.2 , P = 0.107 ).
Real Time PCR showed that, after 12 weeks of treatment with NB-UVB phototherapy or treatment with methotrexate, there was significantly decreased level of miR146a ( P = 0.001 ; P = 0.002 , resp.).
Conclusion.
The expression of miRNA146a is increased in whole blood samples from psoriasis patients, so we can evaluate its possibility to work as a future therapeutic objective in the treatment of psoriasis.
With these markers, it is able to screen therapeutics effect or changes to a further aggressive treatment for psoriasis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ele-Refaei, Asmaa M.& El-Esawy, Fatma. 2015. Effect of Narrow-Band Ultraviolet B Phototherapy and Methotrexate on MicroRNA (146a) Levels in Blood of Psoriatic Patients. Dermatology Research and Practice،Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1061094
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ele-Refaei, Asmaa M.& El-Esawy, Fatma. Effect of Narrow-Band Ultraviolet B Phototherapy and Methotrexate on MicroRNA (146a) Levels in Blood of Psoriatic Patients. Dermatology Research and Practice No. 2015 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1061094
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ele-Refaei, Asmaa M.& El-Esawy, Fatma. Effect of Narrow-Band Ultraviolet B Phototherapy and Methotrexate on MicroRNA (146a) Levels in Blood of Psoriatic Patients. Dermatology Research and Practice. 2015. Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1061094
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1061094
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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