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Purple Sweet Potato Leaf Extract Induces Apoptosis and Reduces Inflammatory Adipokine Expression in 3T3-L1 Differentiated Adipocytes
المؤلفون المشاركون
Lee, Shou-Lun
Chin, Ting-Yu
Tu, Ssu-Chieh
Wang, Yu-Jie
Hsu, Ya-Ting
Wu, Yang-Chang
Kao, Ming-Ching
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-06-11
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background.
Purple sweet potato leaves (PSPL) are widely grown and are considered a healthy vegetable in Taiwan.
PSPL contain a high content of flavonoids, and the boiling water-extracted PSPL (PSPLE) is believed to prevent metabolic syndrome.
However, its efficacy has not yet been verified.
Therefore, we investigated the effect of PSPLE on adipocytes.
Methods.
The differentiated 3T3-L1 cells used in this study were derived from preadipocytes that were differentiated into adipocytes using an adipogenic agent (insulin, dexamethasone, and 3-isobutyl-1-methylxanthine); approximately 90% of the cells were differentiated using this method.
Results.
Treating the differentiated 3T3-L1 cells with PSPLE caused a dose-dependent decrease in the number of adipocytes rather than preadipocytes.
In addition, treatment with PSPLE resulted in apoptosis of the differentiated 3T3-L1 cells as determined by DAPI analysis and flow cytometry.
PSPLE also increased the expression of cleaved caspase-3 and poly ADP-ribose polymerase (PARP).
Furthermore, PSPLE induced downregulation of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) gene expression in the differentiated 3T3-L1 cells.
Conclusions.
These results suggest that PSPLE not only induced apoptosis but also downregulated inflammation-associated genes in the differentiated 3T3-L1 cells.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lee, Shou-Lun& Chin, Ting-Yu& Tu, Ssu-Chieh& Wang, Yu-Jie& Hsu, Ya-Ting& Kao, Ming-Ching…[et al.]. 2015. Purple Sweet Potato Leaf Extract Induces Apoptosis and Reduces Inflammatory Adipokine Expression in 3T3-L1 Differentiated Adipocytes. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1061154
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lee, Shou-Lun…[et al.]. Purple Sweet Potato Leaf Extract Induces Apoptosis and Reduces Inflammatory Adipokine Expression in 3T3-L1 Differentiated Adipocytes. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1061154
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lee, Shou-Lun& Chin, Ting-Yu& Tu, Ssu-Chieh& Wang, Yu-Jie& Hsu, Ya-Ting& Kao, Ming-Ching…[et al.]. Purple Sweet Potato Leaf Extract Induces Apoptosis and Reduces Inflammatory Adipokine Expression in 3T3-L1 Differentiated Adipocytes. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1061154
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1061154
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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