Evaluation of Phototoxic and Skin Sensitization Potentials of PLA2-Free Bee Venom
المؤلفون المشاركون
Heo, Yunwi
Pyo, Min-Jung
Bae, Seong Kyeong
Lee, Hyunkyoung
Kwon, Young Chul
Kim, Je Hein
Kim, Bokyung
Kim, Choul Goo
Kang, Changkeun
Kim, Euikyung
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-08-10
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Bee venom (BV) from honey bee (Apis mellifera L.) has been used in oriental medicine and cosmetic ingredients because of its diverse pharmacological activities.
In many studies, among BV components, phospholipase A2 (PLA2) is known as a major player in BV-induced allergic reaction.
Therefore, we removed PLA2 from BV using ultrafiltration and then investigated in vitro phototoxicity and in vivo skin sensitization of PLA2-free BV (PBV) in comparison with regular BV.
The 3T3 neutral red uptake phototoxicity assay can be appropriated to identify the phototoxic effect of a test substance upon the exposure of ultraviolet A.
Chlorpromazine, a positive control, showed high levels of photoirritation factor and mean photo effect values, while BV and PBV had less of these values.
Local lymph node assay is an alternative method to evaluate skin sensitization potential of chemicals.
BALB/c mice were treated with p-phenylenediamine (PPD, positive control), BV, or PBV.
In all of PPD concentrations, stimulation indexes (SI) as sensitizing potential of chemicals were ≥1.6, determined to be sensitizer, while SI levels of BV and PBV were below 1.6.
Thus, based on these findings, we propose that both BV and PBV are nonphototoxic compounds and nonsensitizers.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Heo, Yunwi& Pyo, Min-Jung& Bae, Seong Kyeong& Lee, Hyunkyoung& Kwon, Young Chul& Kim, Je Hein…[et al.]. 2015. Evaluation of Phototoxic and Skin Sensitization Potentials of PLA2-Free Bee Venom. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1061184
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Heo, Yunwi…[et al.]. Evaluation of Phototoxic and Skin Sensitization Potentials of PLA2-Free Bee Venom. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1061184
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Heo, Yunwi& Pyo, Min-Jung& Bae, Seong Kyeong& Lee, Hyunkyoung& Kwon, Young Chul& Kim, Je Hein…[et al.]. Evaluation of Phototoxic and Skin Sensitization Potentials of PLA2-Free Bee Venom. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1061184
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1061184
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر