In Vitro and In Vivo Antitumor Effects of n-Butanol Extracts of Pterocephalus hookeri on Hep3B Cancer Cell
المؤلفون المشاركون
Guo, Chenxu
Wu, Yingchun
Zhu, Yuanzhang
Wang, Yanchun
Tian, Lili
Lu, Yi
Han, Cong
Zhu, Guofu
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-05-19
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Pterocephalus hookeri is a widely applied Tibetan medicinal prescription for treatment of diseases such as flu, rheumatoid arthritis, and enteritis in China.
It has been reported that Pterocephalus hookeri has anti-inflammatory and analgesic actions.
However, the antitumor activity of Pterocephalus hookeri remains unknown.
In the present study, we demonstrate that n-butanol extracts of Pterocephalus hookeri (YSC-ZDC) has a strong antitumor activity against hepatoma carcinoma cell in vitro and in vivo.
YSC-ZDC inhibited proliferation of all cancer cell lines and significantly inhibited Hep3B cells proliferation in a dose- and time-dependant manner.
Transmission electron microscopy, hoechst 33258 staining, and flow cytometry analysis revealed that YSC-ZDC induced apoptosis in Hep3B cells.
YSC-ZDC treatment dramatically inhibited PDK1 and Akt phosphorylation in Hep3B cells.
Moreover, YSC-ZDC increased Bax expression and inhibited Bcl-2 expression.
In addition, YSC-ZDC inhibited growth hepatoma xenografts in vivo with no effect on body weight and spleen index.
Consistent with results in vitro, YSC-ZDC increased Bax expression and inhibited Bcl-2 expression in tumor tissue.
Taken together, this study shows YSC-ZDC with an antitumor activity both in vitro and in vivo.
Its mechanism underlying is related to blocking of the Akt pathway and regulation of Bcl-2 family proteins expression.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Guo, Chenxu& Wu, Yingchun& Zhu, Yuanzhang& Wang, Yanchun& Tian, Lili& Lu, Yi…[et al.]. 2015. In Vitro and In Vivo Antitumor Effects of n-Butanol Extracts of Pterocephalus hookeri on Hep3B Cancer Cell. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1061190
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Guo, Chenxu…[et al.]. In Vitro and In Vivo Antitumor Effects of n-Butanol Extracts of Pterocephalus hookeri on Hep3B Cancer Cell. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1061190
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Guo, Chenxu& Wu, Yingchun& Zhu, Yuanzhang& Wang, Yanchun& Tian, Lili& Lu, Yi…[et al.]. In Vitro and In Vivo Antitumor Effects of n-Butanol Extracts of Pterocephalus hookeri on Hep3B Cancer Cell. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1061190
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1061190
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر