Combined Effects of Muricid Extract and 5-Fluorouracil on Intestinal Toxicity in Rats
المؤلفون المشاركون
Yazbeck, Roger
Lindsay, Ruth
Abbott, Catherine A.
Howarth, Gordon S.
Benkendorff, Kirsten
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-05-13
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Chemotherapy drugs, such as 5-fluorouracil (5FU), are the standard approach for cancer and are associated with several peripheral toxicities.
We previously demonstrated that Muricidae marine molluscs exhibit chemopreventive properties.
This study investigated the combined effect of muricid extract derived from Dicathais orbita, with 5FU, on intestinal toxicity in rats.
Groups of rats were orally gavaged water, muricid extract, or sunflower oil, with or without 5FU (150 mg/kg).
Metabolic data was collected daily and small intestinal brush border enzyme activity was measured by sucrose breath test (SBT).
Blood was collected by cardiac puncture for whole blood analysis.
Intestinal biopsies were taken for histopathology.
Neutrophil activity was measured by myeloperoxidase activity.
No additional toxicity effects were observed in rats receiving the combination of 5FU and muricid extract compared to 5FU alone, as indicated by SBT, histopathology, and myeloperoxidase activity.
Intestinal integrity was protected from 5FU-induced damage in the sunflower oil vehicle group, compared to controls, as measured by SBT, villus height, and crypt depth.
We concluded that combination of muricid extract and 5FU did not confer any additional intestinal toxicity, further supporting its potential as a chemopreventive food product.
In this model system, sunflower oil partially protected against 5FU-induced intestinal toxicity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yazbeck, Roger& Lindsay, Ruth& Abbott, Catherine A.& Benkendorff, Kirsten& Howarth, Gordon S.. 2015. Combined Effects of Muricid Extract and 5-Fluorouracil on Intestinal Toxicity in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1061201
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yazbeck, Roger…[et al.]. Combined Effects of Muricid Extract and 5-Fluorouracil on Intestinal Toxicity in Rats. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1061201
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yazbeck, Roger& Lindsay, Ruth& Abbott, Catherine A.& Benkendorff, Kirsten& Howarth, Gordon S.. Combined Effects of Muricid Extract and 5-Fluorouracil on Intestinal Toxicity in Rats. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1061201
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1061201
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر