Topical Treatment with Xiaozheng Zhitong Paste (XZP) Alleviates Bone Destruction and Bone Cancer Pain in a Rat Model of Prostate Cancer-Induced Bone Pain by Modulating the RANKLRANKOPG Signaling
المؤلفون المشاركون
Bao, Yanju
Gao, Yebo
Du, Maobo
Hou, Wei
Yang, Liping
Kong, Xiangying
Zheng, Honggang
Li, Weidong
Hua, Baojin
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-01-27
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
To explore the effects and mechanisms of Xiaozheng Zhitong Paste (XZP) on bone cancer pain, Wistar rats were inoculated with vehicle or prostate cancer PC-3 into the tibia bone and treated topically with inert paste, XZP at 15.75, 31.5, or 63 g/kg twice per day for 21 days.
Their bone structural damage, nociceptive behaviors, bone osteoclast and osteoblast activity, and the levels of OPG, RANL, RNAK, PTHrP, IGF-1, M-CSF, IL-8, and TNF-α were examined.
In comparison with that in the placebo group, significantly reduced numbers of invaded cancer cells, decreased levels of bone damage and mechanical threshold and paw withdrawal latency, lower levels of serum TRACP5b, ICTP, PINP, and BAP, and less levels of bone osteoblast and osteoclast activity were detected in the XZP-treated rats ( P < 0.05 ).
Moreover, significantly increased levels of bone OPG but significantly decreased levels of RANL, RNAK, PTHrP, IGF-1, M-CSF, IL-8, and TNF-α were detected in the XZP-treated rats ( P < 0.05 for all).
Together, XZP treatment significantly mitigated the cancer-induced bone damage and bone osteoclast and osteoblast activity and alleviated prostate cancer-induced bone pain by modulating the RANKL/RANK/OPG pathway and bone cancer-related inflammation in rats.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bao, Yanju& Gao, Yebo& Du, Maobo& Hou, Wei& Yang, Liping& Kong, Xiangying…[et al.]. 2015. Topical Treatment with Xiaozheng Zhitong Paste (XZP) Alleviates Bone Destruction and Bone Cancer Pain in a Rat Model of Prostate Cancer-Induced Bone Pain by Modulating the RANKLRANKOPG Signaling. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1061252
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bao, Yanju…[et al.]. Topical Treatment with Xiaozheng Zhitong Paste (XZP) Alleviates Bone Destruction and Bone Cancer Pain in a Rat Model of Prostate Cancer-Induced Bone Pain by Modulating the RANKLRANKOPG Signaling. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-14.
https://search.emarefa.net/detail/BIM-1061252
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bao, Yanju& Gao, Yebo& Du, Maobo& Hou, Wei& Yang, Liping& Kong, Xiangying…[et al.]. Topical Treatment with Xiaozheng Zhitong Paste (XZP) Alleviates Bone Destruction and Bone Cancer Pain in a Rat Model of Prostate Cancer-Induced Bone Pain by Modulating the RANKLRANKOPG Signaling. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1061252
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1061252
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر