Aqueous Date Flesh or Pits Extract Attenuates Liver Fibrosis via Suppression of Hepatic Stellate Cell Activation and Reduction of Inflammatory Cytokines, Transforming Growth Factor-β1 and Angiogenic Markers in Carbon Tetrachloride-Intoxicated Rats
المؤلفون المشاركون
Al-Rasheed, Nouf M.
Attia, Hala A.
Mohamad, Raeesa A.
Al-Rasheed, Nawal M.
Al-Amin, Maha A.
AL-Onazi, Asma
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-19، 19ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-04-06
دولة النشر
مصر
عدد الصفحات
19
التخصصات الرئيسية
الملخص EN
Previous data indicated the protective effect of date fruit extract on oxidative damage in rat liver.
However, the hepatoprotective effects via other mechanisms have not been investigated.
This study was performed to evaluate the antifibrotic effect of date flesh extract (DFE) or date pits extract (DPE) via inactivation of hepatic stellate cells (HSCs), reducing the levels of inflammatory, fibrotic and angiogenic markers.
Coffee was used as reference hepatoprotective agent.
Liver fibrosis was induced by injection of CCl4 (0.4 mL/kg) three times weekly for 8 weeks.
DFE, DPE (6 mL/kg), coffee (300 mg/kg), and combination of coffee + DFE and coffee + DPE were given to CCl4-intoxicated rats daily for 8 weeks.
DFE, DPE, and their combination with coffee attenuated the elevated levels of inflammatory cytokines including tumor necrosis factor-α, interleukin-6, and interleukin-1β.
The increased levels of transforming growth factor-β1 and collagen deposition in injured liver were alleviated by both extracts.
CCl4-induced expression of α-smooth muscle actin was suppressed indicating HSCs inactivation.
Increased angiogenesis was ameliorated as revealed by reduced levels and expression of vascular endothelial growth factor and CD31.
We concluded that DFE or DPE could protect liver via different mechanisms.
The combination of coffee with DFE or DPE may enhance its antifibrotic effects.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Al-Rasheed, Nouf M.& Attia, Hala A.& Mohamad, Raeesa A.& Al-Rasheed, Nawal M.& Al-Amin, Maha A.& AL-Onazi, Asma. 2015. Aqueous Date Flesh or Pits Extract Attenuates Liver Fibrosis via Suppression of Hepatic Stellate Cell Activation and Reduction of Inflammatory Cytokines, Transforming Growth Factor-β1 and Angiogenic Markers in Carbon Tetrachloride-Intoxicated Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-19.
https://search.emarefa.net/detail/BIM-1061275
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Al-Rasheed, Nouf M.…[et al.]. Aqueous Date Flesh or Pits Extract Attenuates Liver Fibrosis via Suppression of Hepatic Stellate Cell Activation and Reduction of Inflammatory Cytokines, Transforming Growth Factor-β1 and Angiogenic Markers in Carbon Tetrachloride-Intoxicated Rats. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-19.
https://search.emarefa.net/detail/BIM-1061275
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Al-Rasheed, Nouf M.& Attia, Hala A.& Mohamad, Raeesa A.& Al-Rasheed, Nawal M.& Al-Amin, Maha A.& AL-Onazi, Asma. Aqueous Date Flesh or Pits Extract Attenuates Liver Fibrosis via Suppression of Hepatic Stellate Cell Activation and Reduction of Inflammatory Cytokines, Transforming Growth Factor-β1 and Angiogenic Markers in Carbon Tetrachloride-Intoxicated Rats. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-19.
https://search.emarefa.net/detail/BIM-1061275
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1061275
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر