Flavonoid 4′-O-Methylkuwanon E from Morus alba Induces the Differentiation of THP-1 Human Leukemia Cells
المؤلفون المشاركون
Šmejkal, Karel
Kollar, Peter
Závalová, Veronika Müller
Keltošová, Stanislava
Trnová, Pavlína
Fedr, Radek
Bárta, Tomáš
Souček, Karel
Hošek, Jan
Hampl, Aleš
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-02-09
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Aims.
In this work we studied cytodifferentiation effects of newly characterized prenyl flavonoid 4′-O-methylkuwanon E (4ME) isolated from white mulberry (Morus alba L.).
Main Methods.
Cell growth and viability were measured by dye exclusion assay; cell cycle and surface antigen CD11b were monitored by flow cytometry.
For the cytodifferentiation of cells the NBT reduction assay was employed.
Regulatory proteins were assessed by western blotting.
Key Findings.
4ME induced dose-dependent growth inhibition of THP-1 cells, which was not accompanied by toxic effect.
Inhibition of cells proliferation caused by 4ME was associated with the accumulation in G1 phase and with downregulation of hyperphosphorylated pRb.
Treatment with 4ME led to significant induction of NBT-reducing activity of PMA stimulated THP-1 cells and upregulation expression of differentiation-associated surface antigen CD11b.
Our results suggest that monocytic differentiation induced by 4ME is connected with up-regulation of p38 kinase activity.
Significance.
Our study provides the first evidence that 4ME induces the differentiation of THP-1 human monocytic leukemia cells and thus is a potential cytodifferentiating anticancer agent.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kollar, Peter& Bárta, Tomáš& Keltošová, Stanislava& Trnová, Pavlína& Závalová, Veronika Müller& Šmejkal, Karel…[et al.]. 2015. Flavonoid 4′-O-Methylkuwanon E from Morus alba Induces the Differentiation of THP-1 Human Leukemia Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1061277
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kollar, Peter…[et al.]. Flavonoid 4′-O-Methylkuwanon E from Morus alba Induces the Differentiation of THP-1 Human Leukemia Cells. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1061277
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kollar, Peter& Bárta, Tomáš& Keltošová, Stanislava& Trnová, Pavlína& Závalová, Veronika Müller& Šmejkal, Karel…[et al.]. Flavonoid 4′-O-Methylkuwanon E from Morus alba Induces the Differentiation of THP-1 Human Leukemia Cells. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1061277
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1061277
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر