Maslinic Acid, a Triterpene from Olive, Affects the Antioxidant and Mitochondrial Status of B16F10 Melanoma Cells Grown under Stressful Conditions
المؤلفون المشاركون
Mokhtari, Khalida
Rufino-Palomares, Eva E.
Pérez-Jiménez, Amalia
Reyes-Zurita, Fernando J.
Figuera, Celeny
García-Salguero, Leticia
Medina, Pedro P.
Peragón, Juan
Lupiáñez, José A.
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-07-07
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Maslinic acid (MA) is a natural compound whose structure corresponds to a pentacyclic triterpene.
It is abundant in the cuticular lipid layer of olives.
MA has many biological and therapeutic properties related to health, including antitumor, anti-inflammatory, antimicrobial, antiparasitic, antihypertensive, and antioxidant activities.
However, no studies have been performed to understand the molecular mechanism induced by this compound in melanoma cancer.
The objective of this study was to examine the effect of MA in melanoma (B16F10) cells grown in the presence or absence of fetal bovine serum (FBS).
We performed cell proliferation measurements, and the reactive oxygen species (ROS) measurements using dihydrorhodamine 123 (DHR 123) and activities of catalase, glucose 6-phosphate dehydrogenase, glutathione S-transferase, and superoxide dismutase.
These changes were corroborated by expression assays.
FBS absence reduced cell viability decreasing IC50 values of MA.
The DHR 123 data showed an increase in the ROS level in the absence of FBS.
Furthermore, MA had an antioxidant effect at lower assayed levels measured as DHR and antioxidant defense.
However, at higher dosages MA induced cellular damage by apoptosis as seen in the results obtained.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mokhtari, Khalida& Rufino-Palomares, Eva E.& Pérez-Jiménez, Amalia& Reyes-Zurita, Fernando J.& Figuera, Celeny& García-Salguero, Leticia…[et al.]. 2015. Maslinic Acid, a Triterpene from Olive, Affects the Antioxidant and Mitochondrial Status of B16F10 Melanoma Cells Grown under Stressful Conditions. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1061303
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mokhtari, Khalida…[et al.]. Maslinic Acid, a Triterpene from Olive, Affects the Antioxidant and Mitochondrial Status of B16F10 Melanoma Cells Grown under Stressful Conditions. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1061303
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mokhtari, Khalida& Rufino-Palomares, Eva E.& Pérez-Jiménez, Amalia& Reyes-Zurita, Fernando J.& Figuera, Celeny& García-Salguero, Leticia…[et al.]. Maslinic Acid, a Triterpene from Olive, Affects the Antioxidant and Mitochondrial Status of B16F10 Melanoma Cells Grown under Stressful Conditions. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1061303
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1061303
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر