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Effect of Ginseng (Panax ginseng) Berry EtOAc Fraction on Cognitive Impairment in C57BL6 Mice under High-Fat Diet Inducement
المؤلفون المشاركون
Park, Chang Hyeon
Park, Seon Kyeong
Seung, Tae Wan
Jin, Dong Eun
Guo, Tianjiao
Heo, Ho Jin
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-06-15
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
High-fat diet-induced obesity leads to type 2 diabetes.
Recently, there has been growing apprehension about diabetes-associated cognitive impairment (DACM).
The effect of ginseng (Panax ginseng) berry ethyl acetate fraction (GBEF) on mice with high-fat diet-induced cognitive impairment was investigated to confirm its physiological function.
C57BL/6 mice were fed a high-fat diet for 5 weeks and then a high-fat diet with GBEF (20 and 50 mg/kg of body weight) for 4 weeks.
After three in vivo behavioral tests (Y-maze, passive avoidance, and Morris water maze tests), blood samples were collected from the postcaval vein for biochemical analysis, and whole brains were prepared for an ex vivo test.
A method based on ultra-performance liquid chromatography (UPLC) accurate-mass quadrupole time-of-flight mass spectrometry (Q-TOF/MS) was used to determine major ginsenosides.
GBEF decreased the fasting blood glucose levels of high-fat diet-induced diabetes mellitus (DM) mice and improved hyperglycemia.
Cognitive behavior tests were examined after setting up the DM mice.
The in vivo experiments showed that mice treated with GBEF exhibited more improved cognitive behavior than DM mice.
In addition, GBEF effectively inhibited the acetylcholinesterase (AChE) activity and malondialdehyde (MDA) levels of DM mice brain tissues.
Q-TOF UPLC/MS analyses of GBEF showed that ginsenoside Re was the major ginsenoside.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Park, Chang Hyeon& Park, Seon Kyeong& Seung, Tae Wan& Jin, Dong Eun& Guo, Tianjiao& Heo, Ho Jin. 2015. Effect of Ginseng (Panax ginseng) Berry EtOAc Fraction on Cognitive Impairment in C57BL6 Mice under High-Fat Diet Inducement. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1061346
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Park, Chang Hyeon…[et al.]. Effect of Ginseng (Panax ginseng) Berry EtOAc Fraction on Cognitive Impairment in C57BL6 Mice under High-Fat Diet Inducement. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1061346
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Park, Chang Hyeon& Park, Seon Kyeong& Seung, Tae Wan& Jin, Dong Eun& Guo, Tianjiao& Heo, Ho Jin. Effect of Ginseng (Panax ginseng) Berry EtOAc Fraction on Cognitive Impairment in C57BL6 Mice under High-Fat Diet Inducement. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1061346
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1061346
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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