Azithromycin versus co-amoxiclav in the treatment of acute suppurative otitis media

الملخص EN

Objective: To compare the use of Azithromycin and co-Amoxiclav in the treatment of symptoms and signs of acute suppurative otitis media in children.

Methods: Children of four months to 12 years of age, attended out-patient Pediatric and ENT clinics at Princess Haya Al-Hussein Hospital in Aqaba from June 2003 to June 2004; with signs and symptoms of acute suppurative otitis media were enrolled in rhe study.

Patients were randomized to receive either Azithromycin 10 mg/kg/day in a single dose for 3 days or co-Amoxiclav 45mg/kg/day in three divided doses for 10 days.

Clinical improvement was evaluated on the 2nd and 4th weeks after therapy.

Results: Satisfactory clinical response was measured regarding symptoms and signs two weeks after the beginning of therapy.

They were 84.6% for Azithromycin and 88% for Co-Amoxiclav.

At day 28, 61 patients (82.4%) were cured on Azithromycin compared with 66 patients (83.5 %) on Co-Amoxiclav.

Conclusion: Azithromycin given for three days and Co-Amoxiclav for ten days had similar efficacy; however, Azithromycin was better tolerated.