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Luteolin Ameliorates Hypertensive Vascular Remodeling through Inhibiting the Proliferation and Migration of Vascular Smooth Muscle Cells
المؤلفون المشاركون
Qiaoshan, Yin
Minxia, Su
Wenjia, Mi
Su, Jie
Xu, Han-Ting
Yu, Jing-Jing
Lei, Jing
Li, Bo
Pang, Min-Xia
Chen, Su-Hong
Lv, Gui-Yuan
Gao, Jian-Li
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-09-30
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Objectives.
Preliminary researches showed that luteolin was used to treat hypertension.
However, it is still unclear whether luteolin has effect on the hypertensive complication such as vascular remodeling.
The present study was designed to investigate the effect of luteolin on the hypertensive vascular remodeling and its molecular mechanism.
Method and Results.
We evaluated the effect of luteolin on aorta thickening of hypertension in spontaneous hypertensive rats (SHRs) and found that luteolin could significantly decrease the blood pressure and media thickness of aorta in vivo.
Luteolin could inhibit angiotensin II- (Ang II-) induced proliferation and migration of vascular smooth muscle cells (VSMCs).
Dichlorofluorescein diacetate (DCFH-DA) staining result showed that luteolin reduced Ang II-stimulated ROS production in VSMCs.
Furthermore, western blot and gelatin zymography results showed that luteolin treatment leaded to a decrease in ERK1/2, p-ERK1/2, p-p38, MMP2, and proliferating cell nuclear antigen (PCNA) protein level.
Conclusion.
These data support that luteolin can ameliorate hypertensive vascular remodeling by inhibiting the proliferation and migration of Ang II-induced VSMCs.
Its mechanism is mediated by the regulation of MAPK signaling pathway and the production of ROS.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Su, Jie& Xu, Han-Ting& Yu, Jing-Jing& Gao, Jian-Li& Lei, Jing& Qiaoshan, Yin…[et al.]. 2015. Luteolin Ameliorates Hypertensive Vascular Remodeling through Inhibiting the Proliferation and Migration of Vascular Smooth Muscle Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1061401
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Su, Jie…[et al.]. Luteolin Ameliorates Hypertensive Vascular Remodeling through Inhibiting the Proliferation and Migration of Vascular Smooth Muscle Cells. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-14.
https://search.emarefa.net/detail/BIM-1061401
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Su, Jie& Xu, Han-Ting& Yu, Jing-Jing& Gao, Jian-Li& Lei, Jing& Qiaoshan, Yin…[et al.]. Luteolin Ameliorates Hypertensive Vascular Remodeling through Inhibiting the Proliferation and Migration of Vascular Smooth Muscle Cells. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1061401
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1061401
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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