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Identification of Proteins Implicated in the Increased Heart Rate in ShenSongYangXin-Treated Bradycardia Rabbits by iTRAQ-Based Quantitative Proteomics
المؤلفون المشاركون
Zhang, Ping
Liu, Zhouying
Huo, Youping
Wei, Cong
Pu, Jielin
Gong, Jing
Zhang, Yinhui
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-12-03
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
The present study tries to identify proteins implicated in bradycardia rabbits in hearts after ShenSongYangXin (SSYX, a traditional Chinese medicine) treatment.
Eighteen adult rabbits were randomly assigned to three groups: sham, model, and SSYX treatment groups.
Heart rate was recorded in rabbits and proteins were isolated from ventricular muscle.
We used isobaric tags for elative and absolute quantitation (iTRAQ) coupled with two-dimensional liquid chromatography-tandem mass spectrometry to identify altered proteins after SSYX treatment.
The heart rate decreased after six weeks due to the injury of the sinoatrial node in the model group.
This effect was partially reversed by 4-week SSYX treatment.
A total of a2988 proteins were quantified by performing the iTRAQ-based experiments.
Of these, 86 proteins were differentially expressed according to our criteria (42 upregulated and 44 downregulated).
The identification of key proteins implicated in the treatment of bradycardia could serve as a foundation to better understand and further explore the molecular mechanism of SSYX treatment.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Zhouying& Zhang, Ping& Huo, Youping& Gong, Jing& Zhang, Yinhui& Wei, Cong…[et al.]. 2015. Identification of Proteins Implicated in the Increased Heart Rate in ShenSongYangXin-Treated Bradycardia Rabbits by iTRAQ-Based Quantitative Proteomics. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1061439
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Zhouying…[et al.]. Identification of Proteins Implicated in the Increased Heart Rate in ShenSongYangXin-Treated Bradycardia Rabbits by iTRAQ-Based Quantitative Proteomics. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1061439
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Zhouying& Zhang, Ping& Huo, Youping& Gong, Jing& Zhang, Yinhui& Wei, Cong…[et al.]. Identification of Proteins Implicated in the Increased Heart Rate in ShenSongYangXin-Treated Bradycardia Rabbits by iTRAQ-Based Quantitative Proteomics. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1061439
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1061439
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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