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Effect of Lactobacillus plantarum Strain K21 on High-Fat Diet-Fed Obese Mice
المؤلفون المشاركون
Tsai, Ying-Chieh
Lai, Wen-Lin
Weng, Wei-Lien
Tsai, Hui-Ping
Liu, Wei-Hsien
Lee, Meng-Hwan
Wu, Chien-Chen
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-02-23
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Recent studies have demonstrated beneficial effects of specific probiotics on alleviating obesity-related disorders.
Here we aimed to identify probiotics with potential antiobesity activity among 88 lactic acid bacterial strains via in vitro screening assays, and a Lactobacillus plantarum strain K21 was found to harbor abilities required for hydrolyzing bile salt, reducing cholesterol, and inhibiting the accumulation of lipid in 3T3-L1 preadipocytes.
Furthermore, effects of K21 on diet-induced obese (DIO) mice were examined.
Male C57Bl/6J mice received a normal diet, high-fat diet (HFD), or HFD with K21 administration (109 CFU in 0.2 mL PBS/day) for eight weeks.
Supplementation of K21, but not placebo, appeared to alleviate body weight gain and epididymal fat mass accumulation, reduce plasma leptin levels, decrease cholesterol and triglyceride levels, and mitigate liver damage in DIO mice.
Moreover, the hepatic expression of peroxisome proliferator-activated receptor-γ (PPAR-γ) related to adipogenesis was significantly downregulated in DIO mice by K21 intervention.
We also found that K21 supplementation strengthens intestinal permeability and modulates the amount of Lactobacillus spp., Bifidobacterium spp., and Clostridium perfringens in the cecal contents of DIO mice.
In conclusion, our results suggest that dietary intake of K21 protects against the onset of HFD-induced obesity through multiple mechanisms of action.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wu, Chien-Chen& Weng, Wei-Lien& Lai, Wen-Lin& Tsai, Hui-Ping& Liu, Wei-Hsien& Lee, Meng-Hwan…[et al.]. 2015. Effect of Lactobacillus plantarum Strain K21 on High-Fat Diet-Fed Obese Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1061447
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wu, Chien-Chen…[et al.]. Effect of Lactobacillus plantarum Strain K21 on High-Fat Diet-Fed Obese Mice. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1061447
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wu, Chien-Chen& Weng, Wei-Lien& Lai, Wen-Lin& Tsai, Hui-Ping& Liu, Wei-Hsien& Lee, Meng-Hwan…[et al.]. Effect of Lactobacillus plantarum Strain K21 on High-Fat Diet-Fed Obese Mice. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1061447
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1061447
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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