The Role of Endophytic Fungi in the Anticancer Activity of Morinda citrifolia Linn. (Noni)
المؤلفون المشاركون
Wu, Yougen
Girmay, Sisay
da Silva, Vitor Martins
Perry, Brian
Hu, Xinwen
Tan, Ghee T.
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-12-10
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
We hypothesize that the fungal endophytes of noni may possibly play a role in its overall pharmacological repertoire, especially since the perceived efficacy of the fruit in ethnomedicinal use is associated with the fermented juice.
The foremost goal of this study is to explore the role of endophyte-derived secondary metabolites in the purported anticancer properties of noni.
To that end, culturable endophytic fungi resident within the healthy leaves and fruit of the plant were isolated and identified by molecular sequence analysis of the 5.8S gene and internal transcribed spacers (ITS).
Purified organisms were subjected to in vitro fermentation in malt extract broth for 8 weeks under anaerobic conditions at room temperature (25°C), in order to simulate the conditions under which traditional fermented noni juice is prepared.
The cytotoxic potential of organic extracts derived from the fermented broths of individual endophytes was then tested against three major cancers that afflict humans.
Twelve distinct endophytic fungal species were obtained from the leaves and 3 from the fruit.
Three of the leaf endophytes inhibited the growth of human carcinoma cell lines LU-1 (lung), PC-3 (prostate), and MCF-7 (breast) with IC50 values of ≤10 μg/mL.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wu, Yougen& Girmay, Sisay& da Silva, Vitor Martins& Perry, Brian& Hu, Xinwen& Tan, Ghee T.. 2015. The Role of Endophytic Fungi in the Anticancer Activity of Morinda citrifolia Linn. (Noni). Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1061451
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wu, Yougen…[et al.]. The Role of Endophytic Fungi in the Anticancer Activity of Morinda citrifolia Linn. (Noni). Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1061451
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wu, Yougen& Girmay, Sisay& da Silva, Vitor Martins& Perry, Brian& Hu, Xinwen& Tan, Ghee T.. The Role of Endophytic Fungi in the Anticancer Activity of Morinda citrifolia Linn. (Noni). Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1061451
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1061451
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر