Effects of Tetramethylpyrazine on Functional Recovery and Neuronal Dendritic Plasticity after Experimental Stroke
المؤلفون المشاركون
Liao, Wei-jing
Lin, Jun-Bin
Zheng, Chan-Juan
Zhang, Xuan
Chen, Juan
Wan, Qi
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-08-26
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
The 2,3,5,6-tetramethylpyrazine (TMP) has been widely used in the treatment of ischemic stroke by Chinese doctors.
Here, we report the effects of TMP on functional recovery and dendritic plasticity after ischemic stroke.
A classical model of middle cerebral artery occlusion (MCAO) was established in this study.
The rats were assigned into 3 groups: sham group (sham operated rats treated with saline), model group (MCAO rats treated with saline) and TMP group (MCAO rats treated with 20 mg/kg/d TMP).
The neurological function test of animals was evaluated using the modified neurological severity score (mNSS) at 3 d, 7 d, and 14 d after MCAO.
Animals were euthanized for immunohistochemical labeling to measure MAP-2 levels in the peri-infarct area.
Golgi-Cox staining was performed to test effect of TMP on dendritic plasticity at 14 d after MCAO.
TMP significantly improved neurological function at 7 d and 14 d after ischemia, increased MAP-2 level at 14 d after ischemia, and enhanced spine density of basilar dendrites.
TMP failed to affect the spine density of apical dendrites and the total dendritic length.
Data analyses indicate that there was significant negative correlation between mNSS and plasticity measured at 14 d after MCAO.
Thus, enhanced dendritic plasticity contributes to TMP-elicited functional recovery after ischemic stroke.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lin, Jun-Bin& Zheng, Chan-Juan& Zhang, Xuan& Chen, Juan& Liao, Wei-jing& Wan, Qi. 2015. Effects of Tetramethylpyrazine on Functional Recovery and Neuronal Dendritic Plasticity after Experimental Stroke. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1061454
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lin, Jun-Bin…[et al.]. Effects of Tetramethylpyrazine on Functional Recovery and Neuronal Dendritic Plasticity after Experimental Stroke. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1061454
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lin, Jun-Bin& Zheng, Chan-Juan& Zhang, Xuan& Chen, Juan& Liao, Wei-jing& Wan, Qi. Effects of Tetramethylpyrazine on Functional Recovery and Neuronal Dendritic Plasticity after Experimental Stroke. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1061454
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1061454
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر