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Evaluation of Antinociceptive Activity of Ethanol Extract of Leaves of Adenanthera pavonina
المؤلفون المشاركون
Moniruzzaman, Md.
Khatun, Ambia
Imam, Mohammad Zafar
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-08-04
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Adenanthera pavonina is a deciduous tree commonly used in the traditional medicine to treat inflammation and rheumatism.
The aim of this study was to evaluate the antinociceptive activity of ethanol extract of leaves of A.
pavonina (EEAP).
EEAP was investigated using various nociceptive models induced thermally or chemically in mice including hot plate and tail immersion test, acetic acid-induced writhing, and glutamate- and formalin-induced licking tests at the doses of 50, 100, and 200 mg/kg body weight (p.o.).
In addition, to assess the possible mechanisms, involvement of opioid system was verified using naloxone (2 mg/kg) and cyclic guanosine monophosphate (cGMP) signaling pathway by methylene blue (MB; 20 mg/kg).
The results have demonstrated that EEAP produced a significant and dose-dependent increment in the hot plate latency and tail withdrawal time.
It also reduced the number of abdominal constrictions and paw lickings induced by acetic acid and glutamate respectively.
EEAP inhibited the nociceptive responses in both phases of formalin test.
Besides, the reversal effects of naloxone indicated the association of opioid receptors on the exertion of EEAP action centrally.
Moreover, the enhancement of writhing inhibitory activity by MB suggests the possible involvement of cGMP pathway in EEAP-mediated antinociception.
These results prove the antinociceptive activity of the leaves of A.
pavonina and support the traditional use of this plant.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Moniruzzaman, Md.& Khatun, Ambia& Imam, Mohammad Zafar. 2015. Evaluation of Antinociceptive Activity of Ethanol Extract of Leaves of Adenanthera pavonina. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1061474
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Moniruzzaman, Md.…[et al.]. Evaluation of Antinociceptive Activity of Ethanol Extract of Leaves of Adenanthera pavonina. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1061474
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Moniruzzaman, Md.& Khatun, Ambia& Imam, Mohammad Zafar. Evaluation of Antinociceptive Activity of Ethanol Extract of Leaves of Adenanthera pavonina. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1061474
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1061474
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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