Suppression of Propionibacterium acnes-Induced Dermatitis by a Traditional Japanese Medicine, Jumihaidokuto, Modifying Macrophage Functions
المؤلفون المشاركون
Kaneko, Atsushi
Iizuka, Seiichi
Sekiguchi, Kyoji
Koseki, Junichi
Tsuchiya, Kazuaki
Matsubara, Yosuke
Imamura, Sachiko
Matsumoto, Takashi
Watanabe, Junko
Yamasaki, Kenshi
Aiba, Setsuya
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-10-01
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Purpose.
Macrophages serve as sweepers of microbes and inflammation-derived wastes and regulators of inflammation.
Some traditional Japanese medicines are reported to have adjuvant effects by modifying macrophages.
Our aim was to characterize the actions of jumihaidokuto (JHT) for treatment of skin inflammations including acne vulgaris, in which Propionibacterium acnes has pathogenic roles.
Methods.
Dermatitis was induced in rat ears by intradermal injection of P.
acnes.
JHT or prednisolone (PDN) was given orally, and ear thickness and histology were evaluated.
The effects of constituents and metabolites of JHT on monocytes were tested by cell-based assays using the human monocytic THP-1 cell.
Results.
JHT and PDN suppressed the ear thickness induced by P.
acnes injection.
Histological examinations revealed that JHT, but not PDN, promoted macrophage accumulation at 24 h after the injection.
PDN suppressed the macrophage chemokine MCP-1 in the inflamed ears, while JHT did not affect it.
The JHT constituents liquiritigenin and isoliquiritin increased expression of CD86 (type-1 macrophage marker) and CD192 (MCP-1 receptor) and enhanced phagocytosis by THP-1.
Conclusions.
JHT suppressed dermatitis, probably by enhancing type-1 macrophage functions, with an action different from PDN.
JHT may be a beneficial drug in treatment of skin inflammation induced by P.
acnes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sekiguchi, Kyoji& Koseki, Junichi& Tsuchiya, Kazuaki& Matsubara, Yosuke& Iizuka, Seiichi& Imamura, Sachiko…[et al.]. 2015. Suppression of Propionibacterium acnes-Induced Dermatitis by a Traditional Japanese Medicine, Jumihaidokuto, Modifying Macrophage Functions. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1061505
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sekiguchi, Kyoji…[et al.]. Suppression of Propionibacterium acnes-Induced Dermatitis by a Traditional Japanese Medicine, Jumihaidokuto, Modifying Macrophage Functions. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1061505
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sekiguchi, Kyoji& Koseki, Junichi& Tsuchiya, Kazuaki& Matsubara, Yosuke& Iizuka, Seiichi& Imamura, Sachiko…[et al.]. Suppression of Propionibacterium acnes-Induced Dermatitis by a Traditional Japanese Medicine, Jumihaidokuto, Modifying Macrophage Functions. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1061505
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1061505
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر