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Oral Administration of Ganoderma lucidum to Lead-Exposed Rats Protects Erythrocytes against Hemolysis: Implicates to Anti-Anemia
المؤلفون المشاركون
Shahdat, Hossain Md
Bhowmick, Sujan
Islam, Saiful
Rozario, Liza
Jahan, Sabrin
Hassan, Mehedi
Sarkar, Marzan
Choudhury, Bazlul Karim
Ahmed, Sohel
Shahjalal, Hussain
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-08-02
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
We studied the effect of chronic oral exposure to lead acetate (PbA) on the sensitivity of RBC to hemolysis and whether the sensitivity could be decreased by feeding the rats with extract of medicinal mushroom Ganoderma lucidum.
Three groups of rats, control, PbA-exposed, and G.
lucidum (Gl)+PbA, were used.
PbA (3 mM) was administered via drinking water and G.
lucidum extract by gavage at 300 mg/Kg BW/day for 12 weeks.
Afterwards, the rats were killed and washed RBCs were subjected to hemolysis in the presence of Fenton’s reagents.
Hemolysis was determined by estimating the amount of released hemoglobin.
The levels of lipid peroxide (LPO) and GSH were determined from RBC membranes and whole RBCs, respectively.
The levels of TNFα and LPO also were determined from hepatic tissues.
The RBCs of PbA-exposed rats displayed significantly higher sensitivity to hemolysis than those of the Gl+PbA rats.
The levels of LPO increased and GSH decreased in the RBCs, with concomitant increases in the levels of hepatic TNFα and LPO in the PbA-exposed rats.
The degree of hemolysis was significantly low in the RBCs of Gl+PbA rats, concurrently with amelioration of hepatic parameters.
Finally, the study suggests that PbA-induced-hemolysis and related oxidative-toxicity might be minimized by consumption of G.
lucidum.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Shahdat, Hossain Md& Bhowmick, Sujan& Islam, Saiful& Rozario, Liza& Jahan, Sabrin& Hassan, Mehedi…[et al.]. 2015. Oral Administration of Ganoderma lucidum to Lead-Exposed Rats Protects Erythrocytes against Hemolysis: Implicates to Anti-Anemia. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1061528
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shahdat, Hossain Md…[et al.]. Oral Administration of Ganoderma lucidum to Lead-Exposed Rats Protects Erythrocytes against Hemolysis: Implicates to Anti-Anemia. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1061528
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Shahdat, Hossain Md& Bhowmick, Sujan& Islam, Saiful& Rozario, Liza& Jahan, Sabrin& Hassan, Mehedi…[et al.]. Oral Administration of Ganoderma lucidum to Lead-Exposed Rats Protects Erythrocytes against Hemolysis: Implicates to Anti-Anemia. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1061528
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1061528
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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