Chemical Composition and Disruption of Quorum Sensing Signaling in Geographically Diverse United States Propolis

المؤلفون المشاركون

Savka, Michael A.
Dailey, Lucas
Popova, Milena
Mihaylova, Ralitsa
Merritt, Benjamin
Masek, Marissa
Le, Phuong
Nor, Sharifah Radziah Mat
Ahmad, Muhammad
Bankova, Vassya
Hudson, André O.

المصدر

Evidence-Based Complementary and Alternative Medicine

العدد

المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-10، 10ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2015-04-15

دولة النشر

مصر

عدد الصفحات

10

التخصصات الرئيسية

الطب البشري

الملخص EN

Propolis or bee glue has been used for centuries for various purposes and is especially important in human health due to many of its biological and pharmacological properties.

In this work we showed quorum sensing inhibitory (QSI) activity of ten geographically distinct propolis samples from the United States using the acyl-homoserine lactone- (AHL-) dependent Chromobacterium violaceum strain CV026.

Based on GC-MS chemical profiling the propolis samples can be classified into several groups that are as follows: (1) rich in cinnamic acid derivatives, (2) rich in flavonoids, and (3) rich in triterpenes.

An in-depth analysis of the propolis from North Carolina led to the isolation and identification of a triterpenic acid that was recently isolated from Hondurian propolis (Central America) and ethyl ether of p-coumaric alcohol not previously identified in bee propolis.

QSI activity was also observed in the second group US propolis samples which contained the flavonoid pinocembrin in addition to other flavonoid compounds.

The discovery of compounds that are involved in QSI activity has the potential to facilitate studies that may lead to the development of antivirulence therapies that can be complementary and/or alternative treatments against antibiotic resistant bacterial pathogens and/or emerging pathogens that have yet to be identified.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Savka, Michael A.& Dailey, Lucas& Popova, Milena& Mihaylova, Ralitsa& Merritt, Benjamin& Masek, Marissa…[et al.]. 2015. Chemical Composition and Disruption of Quorum Sensing Signaling in Geographically Diverse United States Propolis. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1061540

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Savka, Michael A.…[et al.]. Chemical Composition and Disruption of Quorum Sensing Signaling in Geographically Diverse United States Propolis. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1061540

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Savka, Michael A.& Dailey, Lucas& Popova, Milena& Mihaylova, Ralitsa& Merritt, Benjamin& Masek, Marissa…[et al.]. Chemical Composition and Disruption of Quorum Sensing Signaling in Geographically Diverse United States Propolis. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1061540

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1061540