Protective Effect of Artemisia asiatica Extract and Its Active Compound Eupatilin against Cisplatin-Induced Renal Damage
المؤلفون المشاركون
Park, Jun Yeon
Lee, Dahae
Jang, Hyuk-Jai
Jang, Dae Sik
Kwon, Hak Cheol
Kim, Ki Hyun
Kim, Su-Nam
Hwang, Gwi Seo
Kang, Ki Sung
Eom, Dae-Woon
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-10-11
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
The present study investigated the renoprotective effect of an Artemisia asiatica extract and eupatilin in kidney epithelial (LLC-PK1) cells.
Although cisplatin is effective against several cancers, its use is limited due to severe nephrotoxicity.
Eupatilin is a flavonoid compound isolated from the Artemisia plant and possesses antioxidant as well as potent anticancer properties.
In the LLC-PK1 cellular model, the decline in cell viability induced by oxidative stress, such as that induced by cisplatin, was significantly and dose-dependently inhibited by the A.
asiatica extract and eupatilin.
The increased protein expressions of phosphorylated JNK and p38 by cisplatin in cells were markedly reduced after A.
asiatica extract or eupatilin cotreatment.
The elevated expression of cleaved caspase-3 was significantly reduced by A.
asiatica extract and eupatilin, and the elevated percentage of apoptotic cells after cisplatin treatment in LLC-PK1 cells was markedly decreased by cotreatment with A.
asiatica extract or eupatilin.
Taken together, these results suggest that A.
asiatica extract and eupatilin could cure or prevent cisplatin-induced renal toxicity without any adverse effect; thus, it can be used in combination with cisplatin to prevent nephrotoxicity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Park, Jun Yeon& Lee, Dahae& Jang, Hyuk-Jai& Jang, Dae Sik& Kwon, Hak Cheol& Kim, Ki Hyun…[et al.]. 2015. Protective Effect of Artemisia asiatica Extract and Its Active Compound Eupatilin against Cisplatin-Induced Renal Damage. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1061556
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Park, Jun Yeon…[et al.]. Protective Effect of Artemisia asiatica Extract and Its Active Compound Eupatilin against Cisplatin-Induced Renal Damage. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1061556
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Park, Jun Yeon& Lee, Dahae& Jang, Hyuk-Jai& Jang, Dae Sik& Kwon, Hak Cheol& Kim, Ki Hyun…[et al.]. Protective Effect of Artemisia asiatica Extract and Its Active Compound Eupatilin against Cisplatin-Induced Renal Damage. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1061556
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1061556
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر