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Preparation, Characterization, and Pharmacological Activity of Cymbopogon winterianus Jowitt ex Bor (Poaceae) Leaf Essential Oil of β-Cyclodextrin Inclusion Complexes
المؤلفون المشاركون
Araújo, Adriano Antunes de Souza
Blank, Arie Fitzgerald
Alves, Péricles Barreto
Brito, Renan G.
Santos, Priscila L.
Oliveira, Makson G. B.
La Rocca, Viviana
Quintans Júnior, Lucindo José
Serafini, Mairim Russo
Santos, Márcio Roberto Viana
de Almeida, Reinaldo Nóbrega
Lucca Júnior, Waldecy De
Quintans, Jullyana S. S.
Menezes, Paula dos Passos
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-07-13
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
This study aimed to evaluate the orofacial antinociceptive effect of the Cymbopogon winterianus essential oil (LEO) complexed in β-cyclodextrin (LEO-CD) and to assess the possible involvement of the central nervous system (CNS).
The LEO was extracted, chromatographed, and complexed in β-cyclodextrin.
The complex was characterized by differential scanning calorimetry (DSC) and thermogravimetry derivative (TG/DTG).
Male Swiss mice (2-3 months) were treated with LEO-CD (50–200 mg/kg, p.o.), vehicle (distilled water, p.o.), or standard drug (i.p.) and subjected to the orofacial nociception formalin-, capsaicin-, and glutamate-induced.
After the formalin test, the animals were perfused and the brains subjected to immunofluorescence for Fos.
The rota-rod test (7 rpm/min) was carried out.
Geraniol (37.57%) was the main compound of LEO.
DSC and TG/DTG proved the complexation.
The orofacial nociceptive behavior was significantly (p<0.05) reduced.
The number of Fos-positive cells was significantly changed in the dorsal raphe nucleus (p<0.01), locus coeruleus (p<0.001), trigeminal nucleus (p<0.05), and trigeminal thalamic tract (p<0.05).
LEO-CD did not cause changes in motor coordination in the rota-rod test.
Thus, our results suggested that LEO-CD has an orofacial antinociceptive profile, probably mediated by the activation of the CNS without changing the motor coordination.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Santos, Priscila L.& Araújo, Adriano Antunes de Souza& Quintans, Jullyana S. S.& Oliveira, Makson G. B.& Brito, Renan G.& Serafini, Mairim Russo…[et al.]. 2015. Preparation, Characterization, and Pharmacological Activity of Cymbopogon winterianus Jowitt ex Bor (Poaceae) Leaf Essential Oil of β-Cyclodextrin Inclusion Complexes. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1061566
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Santos, Priscila L.…[et al.]. Preparation, Characterization, and Pharmacological Activity of Cymbopogon winterianus Jowitt ex Bor (Poaceae) Leaf Essential Oil of β-Cyclodextrin Inclusion Complexes. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1061566
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Santos, Priscila L.& Araújo, Adriano Antunes de Souza& Quintans, Jullyana S. S.& Oliveira, Makson G. B.& Brito, Renan G.& Serafini, Mairim Russo…[et al.]. Preparation, Characterization, and Pharmacological Activity of Cymbopogon winterianus Jowitt ex Bor (Poaceae) Leaf Essential Oil of β-Cyclodextrin Inclusion Complexes. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1061566
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1061566
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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