Salutary Effects of Cepharanthine against Skeletal Muscle and Kidney Injuries following Limb IschemiaReperfusion
المؤلفون المشاركون
Kao, Ming-Chang
Chung, Chih-Yang
Chang, Ya-Ying
Lin, Chih-Kung
Huang, Chun-Jen
Sheu, Joen-Rong
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-10-26
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Limb ischemia/reperfusion (I/R) causes oxidation and inflammation and subsequently induces muscle and kidney injuries.
Cepharanthine, a natural plant alkaloid, possesses anti-inflammatory and antioxidative properties.
We elucidated the salutary effects of cepharanthine against muscle and kidney injuries following limb I/R.
Adult male rats were randomized to receive I/R or I/R plus cepharanthine.
I/R was achieved by applying tourniquet high around each thigh for 3 hours followed by reperfusion for 24 hours.
Cepharanthine (10 mg/kg, intraperitoneal) was injected immediately before reperfusion.
After euthanization, degrees of tissue injury, inflammation, and oxidation were examined.
Our data revealed that the I/R group had significant increases in injury biomarker concentrations of muscle (creatine kinase and lactate dehydrogenase) and kidney (creatinine, neutrophil gelatinase-associated lipocalin, and kidney injury molecule-1).
Histological assays revealed moderate muscle and kidney injury characteristics in the I/R group.
The I/R group also had significant increases in concentrations of inflammatory molecules (interleukin-6, macrophage inflammatory protein-2, and prostaglandin E2) and reactive nitrogen species (nitric oxide) as well as lipid peroxidation (malondialdehyde).
Of note, these effects of limb I/R could be mitigated by cepharanthine.
These data confirmed that cepharanthine attenuated muscle and kidney injuries induced by limb I/R.
The mechanisms may involve its anti-inflammatory and antioxidative capacities.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kao, Ming-Chang& Chung, Chih-Yang& Chang, Ya-Ying& Lin, Chih-Kung& Sheu, Joen-Rong& Huang, Chun-Jen. 2015. Salutary Effects of Cepharanthine against Skeletal Muscle and Kidney Injuries following Limb IschemiaReperfusion. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1062387
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kao, Ming-Chang…[et al.]. Salutary Effects of Cepharanthine against Skeletal Muscle and Kidney Injuries following Limb IschemiaReperfusion. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1062387
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kao, Ming-Chang& Chung, Chih-Yang& Chang, Ya-Ying& Lin, Chih-Kung& Sheu, Joen-Rong& Huang, Chun-Jen. Salutary Effects of Cepharanthine against Skeletal Muscle and Kidney Injuries following Limb IschemiaReperfusion. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1062387
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1062387
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر