Gas Chromatography-Mass Spectrometry Analysis of Ulva fasciata (Green Seaweed) Extract and Evaluation of Its Cytoprotective and Antigenotoxic Effects
المؤلفون المشاركون
Hernández-Ojeda, S.
Rodeiro, Idania
Olguín, Sitlali
Santes, Rebeca
Herrera, José A.
Mangas, Raisa
Hernández, Yasnay
Fernández, Gisselle
Hernández, Ivones
Valencia-Olvera, Ana
Espinosa-Aguirre, Jesús Javier
Pérez, Carlos
Camacho-Carranza, Rafael
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-11-03
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
The chemical composition and biological properties of Ulva fasciata aqueous-ethanolic extract were examined.
Five components were identified in one fraction prepared from the extract by gas chromatography-mass spectrometry, and palmitic acid and its ethyl ester accounted for 76% of the total identified components.
Furthermore, we assessed the extract’s antioxidant properties by using the DPPH, ABTS, and lipid peroxidation assays and found that the extract had a moderate scavenging effect.
In an experiment involving preexposition and coexposition of the extract (1–500 µg/mL) and benzo[a]pyrene (BP), the extract was found to be nontoxic to C9 cells in culture and to inhibit the cytotoxicity induced by BP.
As BP is biotransformed by CYP1A and CYP2B subfamilies, we explored the possible interaction of the extract with these enzymes.
The extract (25–50 µg/mL) inhibited CYP1A1 activity in rat liver microsomes.
Analysis of the inhibition kinetics revealed a mixed-type inhibitory effect on CYP1A1 supersome.
The effects of the extract on BP-induced DNA damage and hepatic CYP activity in mice were also investigated.
Micronuclei induction by BP and liver CYP1A1/2 activities significantly decreased in animals treated with the extract.
The results suggest that Ulva fasciata aqueous-ethanolic extract inhibits BP bioactivation and it may be a potential chemopreventive agent.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Rodeiro, Idania& Olguín, Sitlali& Santes, Rebeca& Herrera, José A.& Pérez, Carlos& Mangas, Raisa…[et al.]. 2015. Gas Chromatography-Mass Spectrometry Analysis of Ulva fasciata (Green Seaweed) Extract and Evaluation of Its Cytoprotective and Antigenotoxic Effects. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1062413
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Rodeiro, Idania…[et al.]. Gas Chromatography-Mass Spectrometry Analysis of Ulva fasciata (Green Seaweed) Extract and Evaluation of Its Cytoprotective and Antigenotoxic Effects. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1062413
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Rodeiro, Idania& Olguín, Sitlali& Santes, Rebeca& Herrera, José A.& Pérez, Carlos& Mangas, Raisa…[et al.]. Gas Chromatography-Mass Spectrometry Analysis of Ulva fasciata (Green Seaweed) Extract and Evaluation of Its Cytoprotective and Antigenotoxic Effects. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1062413
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1062413
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر