![](/images/graphics-bg.png)
Hepatoprotective Effect of Terminalia chebula against t-BHP-Induced Acute Liver Injury in C57BL6 Mice
المؤلفون المشاركون
Han, Jong-Min
Lee, Jin-Seok
Choi, Min-Kyung
Kim, Hyeong-Geug
Lee, Jong Suk
Chung, Sun Ho
Son, Chang Gue
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-01-26
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
We aimed to identify the hepatoprotective effects of Terminalia chebula water extract (TCW) and its corresponding pharmacological actions using C57/BL6 mice model of tert-butylhydroperoxide-(t-BHP-) induced acute liver injury.
Mice were orally administered with TCW (0, 50, 100, or 200 mg/kg) or gallic acid (100 mg/kg) for 5 days before t-BHP (2.5 mM/kg) injection.
Liver enzymes, histopathology, oxidative stress parameters, antioxidant components, and inflammatory cytokines were examined 18 h after t-BHP injection.
t-BHP injection caused dramatic elevation of serum AST, ALT, and LDH level, while TCW pretreatment notably attenuated these elevations.
Inflammatory cytokines including TNF-α, IL-1β, and IL-6 were notably increased in hepatic tissues, and then these were efficiently attenuated by TCW pretreatment.
t-BHP injection notably increased malondialdehyde, total reactive oxygen species, and nitric oxide in the liver tissue, while it markedly dropped the antioxidant activities including total antioxidant capacity, total glutathione contents, glutathione peroxidase, superoxide dismutase, and catalase.
TCW pretreatment remarkably ameliorated these alterations, and these effects were relevant to gene expressions.
Histopathological examinations supported the above findings.
Collectively, these findings well prove that TCW beneficially prevents acute and severe liver injury and clarify its corresponding mechanisms involved in the inhibition of oxidative stress and inflammatory cytokines.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Choi, Min-Kyung& Kim, Hyeong-Geug& Han, Jong-Min& Lee, Jin-Seok& Lee, Jong Suk& Chung, Sun Ho…[et al.]. 2015. Hepatoprotective Effect of Terminalia chebula against t-BHP-Induced Acute Liver Injury in C57BL6 Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1062475
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Choi, Min-Kyung…[et al.]. Hepatoprotective Effect of Terminalia chebula against t-BHP-Induced Acute Liver Injury in C57BL6 Mice. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1062475
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Choi, Min-Kyung& Kim, Hyeong-Geug& Han, Jong-Min& Lee, Jin-Seok& Lee, Jong Suk& Chung, Sun Ho…[et al.]. Hepatoprotective Effect of Terminalia chebula against t-BHP-Induced Acute Liver Injury in C57BL6 Mice. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1062475
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1062475
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)