Hepatoprotective Effect of Silymarin (Silybum marianum) on Hepatotoxicity Induced by Acetaminophen in Spontaneously Hypertensive Rats
المؤلفون المشاركون
Grespan, Renata
Cuman, Roberto Kenji Nakamura
Caparroz-Assef, Silvana Martins
Silva-Comar, Francielli Maria de Souza
Aguiar, Rafael Pazinatto
Freitag, Abel Felipe
Cardia, Gabriel Fernando Esteves
Spironello, Ricardo Alexandre
da Rocha, Bruno Ambrósio
Bersani-Amado, Ciomar Aparecida
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-03-02
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
This study was aimed to investigate the effect of Silymarin (SLM) on the hypertension state and the liver function changes induced by acetaminophen (APAP) in spontaneously hypertensive rat (SHR).
Animals normotensive (N) or hypertensive (SHR) were treated or not with APAP (3 g/kg, oral) or previously treated with SLM.
Twelve hours after APAP administration, plasmatic levels of liver function markers: alanine aminotransferase (ALT), aspartate aminotransferase (AST), glucose (GLU), gamma glutamyl transferase (γ-GT), and alkaline phosphatase (ALP) of all groups, were determined.
Liver injury was assessed using histological studies.
Samples of their livers were then used to determine the myeloperoxidase (MPO) activity and nitric oxide (NO) production and were also sectioned for histological analysis.
No differences were observed for ALT, γ-GT, and GLU levels between SHR and normotensive rats groups.
However, AST and ALP levels were increased in hypertensive animals.
APAP treatment promoted an increase in ALT and AST in both SHR and N.
However, only for SHR, γ-GT levels were increased.
The inflammatory response evaluated by MPO activity and NO production showed that SHR was more susceptible to APAP effect, by increasing leucocyte infiltration.
Silymarin treatment (Legalon) restored the hepatocyte functional and histopathological alterations induced by APAP in normotensive and hypertensive animals.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Freitag, Abel Felipe& Cardia, Gabriel Fernando Esteves& da Rocha, Bruno Ambrósio& Aguiar, Rafael Pazinatto& Silva-Comar, Francielli Maria de Souza& Spironello, Ricardo Alexandre…[et al.]. 2015. Hepatoprotective Effect of Silymarin (Silybum marianum) on Hepatotoxicity Induced by Acetaminophen in Spontaneously Hypertensive Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1062489
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Freitag, Abel Felipe…[et al.]. Hepatoprotective Effect of Silymarin (Silybum marianum) on Hepatotoxicity Induced by Acetaminophen in Spontaneously Hypertensive Rats. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1062489
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Freitag, Abel Felipe& Cardia, Gabriel Fernando Esteves& da Rocha, Bruno Ambrósio& Aguiar, Rafael Pazinatto& Silva-Comar, Francielli Maria de Souza& Spironello, Ricardo Alexandre…[et al.]. Hepatoprotective Effect of Silymarin (Silybum marianum) on Hepatotoxicity Induced by Acetaminophen in Spontaneously Hypertensive Rats. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1062489
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1062489
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر