Vitis vinifera (Muscat Variety) Seed Ethanolic Extract Preserves Activity Levels of Enzymes and Histology of the Liver in Adult Male Rats with Diabetes
المؤلفون المشاركون
Muniandy, Sekaran
Giribabu, Nelli
Swapna Rekha, Somesula
Eswar Kumar, Kilari
Salleh, N.
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-03-17
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
The effect of V.
vinifera seeds on carbohydrate metabolizing enzymes and other enzymes of the liver in diabetes is currently unknown.
We therefore investigated changes in the activity levels of these enzymes following V.
vinifera seed extract administration to diabetic rats.
Methods.
V.
vinifera seed ethanolic extract (250 and 500 mg/kg/day) or glibenclamide (600 μg/kg/day) was administered to streptozotocin-induced male diabetic rats for 28 consecutive days.
At the end of treatment, liver was harvested and activity levels of various liver enzymes were determined.
Levels of thiobarbituric acid reactive substances (TBARS) were measured in liver homogenates and liver histopathological changes were observed.
Results.
V.
vinifera seed ethanolic extract was able to prevent the decrease in ICDH, SDH, MDH, and G-6-PDH and the increase in LDH activity levels in liver homogenates.
The seed extract also caused serum levels of ALT, AST, ALP, ACP, GGT, and total bilirubin to decrease while causing total proteins to increase.
Additionally, the levels of ALT, AST, and TBARS in liver homogenates were decreased.
Histopathological changes in the liver were reduced.
Conclusion.
Near normal activity levels of various enzymes and histology of the liver following V.
vinifera seed ethanolic extract administration may be due to decrease in liver oxidative stress in diabetes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Giribabu, Nelli& Eswar Kumar, Kilari& Swapna Rekha, Somesula& Muniandy, Sekaran& Salleh, N.. 2015. Vitis vinifera (Muscat Variety) Seed Ethanolic Extract Preserves Activity Levels of Enzymes and Histology of the Liver in Adult Male Rats with Diabetes. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1063324
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Giribabu, Nelli…[et al.]. Vitis vinifera (Muscat Variety) Seed Ethanolic Extract Preserves Activity Levels of Enzymes and Histology of the Liver in Adult Male Rats with Diabetes. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1063324
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Giribabu, Nelli& Eswar Kumar, Kilari& Swapna Rekha, Somesula& Muniandy, Sekaran& Salleh, N.. Vitis vinifera (Muscat Variety) Seed Ethanolic Extract Preserves Activity Levels of Enzymes and Histology of the Liver in Adult Male Rats with Diabetes. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1063324
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1063324
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر