Study of the Gastroprotective Effect of Extracts and Semipurified Fractions of Chresta martii DC. and Identification of Its Principal Compounds
المؤلفون المشاركون
Franco, E. S.
Mélo, M. E. B.
Jatobá, B. J. A.
Santana, A. L. B. D.
Nascimento, M. S.
Maia, Maria Bernadete de Sousa
e Silva, Antonio Alfredo Rodrigues
da Silva, Teresinha Gonçalves
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-03-17
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Chresta martii (Asteraceae) is a species widely used by the population of the Xingu region of Sergipe, Brazil, in the form of a decoction (aerial parts) for the treatment of gastrointestinal diseases.
The study aims to assess the gastroprotective activity of organic extracts and semipurified fractions and identify the principal compounds present in C.
martii responsible for such activity.
The organic extracts (cyclohexane: ECCm, ethyl acetate: EACm, and ethanol: EECm) were obtained from the dried aerial parts (500 g) of C.
martii.
For evaluation of the gastroprotective activity of extracts (50, 100, or 200 mg/kg; p.o.), male Swiss Webster mice (25–30 g) were used which had gastric ulcers induced by indomethacin (40 mg/kg, s.c.) or ethanol (0.2 mL/animal; p.o.).
Among the extracts evaluated, EACm exhibited significant ( P < 0.05 ) gastroprotective activity in the models used.
The fractionation of EACm was performed in a silica gel column 60 eluted with the following compounds: [chloroform—F1 yield (10%)], [chloroform/ethyl acetate (1/1)—F2 yield (6%)], [ethyl acetate—F3 yield (8%)], and [ethyl/methanol acetate (1/1)—F4 yield (5%)].
Of the fractions described above, the F1 (25 mg/kg; p.o.) had greater gastroprotective activity ( P < 0.05 ) than that displayed by ranitidine (80 mg/kg; p.o.) in the ethanol-induced ulcer model.
The refractionation of F1 produced 23 subfractions and from these two yellow amorphous compounds were obtained by recrystallization, Rf: 0.46 and 0.31 (ethyl acetate : chloroform 5 : 5).
The compounds isolated were characterized by nuclear magnetic resonance spectroscopy (1H-NMR and 13C-NMR) and identified as flavones: chrysoeriol (yield: 0.43%) and 3′,4′-dimethoxyluteolin (yield: 0.58%).
Conclusion.
Flavone 3′,4′-dimethoxyluteolin is the principal compound present in the species C.
martii and is probably responsible for gastroprotective activity observed in this species.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Franco, E. S.& Mélo, M. E. B.& Jatobá, B. J. A.& Santana, A. L. B. D.& e Silva, Antonio Alfredo Rodrigues& da Silva, Teresinha Gonçalves…[et al.]. 2015. Study of the Gastroprotective Effect of Extracts and Semipurified Fractions of Chresta martii DC. and Identification of Its Principal Compounds. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1063342
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Franco, E. S.…[et al.]. Study of the Gastroprotective Effect of Extracts and Semipurified Fractions of Chresta martii DC. and Identification of Its Principal Compounds. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1063342
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Franco, E. S.& Mélo, M. E. B.& Jatobá, B. J. A.& Santana, A. L. B. D.& e Silva, Antonio Alfredo Rodrigues& da Silva, Teresinha Gonçalves…[et al.]. Study of the Gastroprotective Effect of Extracts and Semipurified Fractions of Chresta martii DC. and Identification of Its Principal Compounds. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1063342
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1063342
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر