Antiviral and Antioxidant Activities of Sulfated Galactomannans from Plants of Caatinga Biome
المؤلفون المشاركون
de Morais, Selene Maia
Marques, Márcia Maria Mendes
Silva, Ana Raquel Araújo da
Barroso, Naiara Dutra
Pontes Filho, Tadeu Rocha
Araújo, Fernanda Montenegro de Carvalho
Vieira, Ícaro Gusmão Pinto
Lima, Danielle Malta
Guedes, Maria Izabel Florindo
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-07-14
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Dengue represents a serious social and economic public health problem; then trying to contribute to improve its control, the objective of this research was to develop phytoterapics for dengue treatment using natural resources from Caatinga biome.
Galactomannans isolated from Adenanthera pavonina L., Caesalpinia ferrea Mart., and Dimorphandra gardneriana Tull were chemically sulfated in order to evaluate the antioxidant, and antiviral activities and the role in the inhibition of virus DENV-2 in Vero cells.
A positive correlation between the degree of sulfation, antioxidant and antiviral activities was observed.
The sulfated galactomannans showed binding to the virus surface, indicating that they interact with DENV-2.
The sulfated galactomannans from C.
ferrea showed 96% inhibition of replication of DENV-2 followed by D.
gardneriana (94%) and A.
pavonina (77%) at 25 µg/mL and all sulfated galactomannans also showed antioxidant activity.
This work is the first report of the antioxidant and antiviral effects of sulfated galactomannans against DENV-2.
The results are very promising and suggest that these sulfated galactomannans from plants of Caatinga biome act in the early step of viral infection.
Thus, sulfated galactomannans may act as an entry inhibitor of DENV-2.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Marques, Márcia Maria Mendes& de Morais, Selene Maia& Silva, Ana Raquel Araújo da& Barroso, Naiara Dutra& Pontes Filho, Tadeu Rocha& Araújo, Fernanda Montenegro de Carvalho…[et al.]. 2015. Antiviral and Antioxidant Activities of Sulfated Galactomannans from Plants of Caatinga Biome. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1063356
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Marques, Márcia Maria Mendes…[et al.]. Antiviral and Antioxidant Activities of Sulfated Galactomannans from Plants of Caatinga Biome. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1063356
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Marques, Márcia Maria Mendes& de Morais, Selene Maia& Silva, Ana Raquel Araújo da& Barroso, Naiara Dutra& Pontes Filho, Tadeu Rocha& Araújo, Fernanda Montenegro de Carvalho…[et al.]. Antiviral and Antioxidant Activities of Sulfated Galactomannans from Plants of Caatinga Biome. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1063356
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1063356
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر