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Antinociceptive Effect of the Essential Oil Obtained from the Leaves of Croton cordiifolius Baill. (Euphorbiaceae) in Mice
المؤلفون المشاركون
Araújo, Renata M.
Havt, Alexandre
Nogueira, Lenise de Morais
da Silva, Monalisa Ribeiro
Santos, Simone Maria dos
Ferraz, Igor Cavalcanti
Albuquerque, Thaíse Torres de
Mota, Carlos Renato França de Carvalho
Martins, René Duarte
de Albuquerque, Julianna Ferreira Cavalcanti
Viana, Glauce Socorro de Barros
Ximenes, Rafael Matos
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-03-02
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Croton cordiifolius Baill.
is a shrub known as “quebra-faca” and is used to treat inflammation, pain, wounds, and gastrointestinal disturbances in the semiarid region in the northeast of Brazil.
In an ethnobotanical survey in the state of Pernambuco, “quebra-faca” use was cited in 33% of the interviews.
Thus, we decided to evaluate the antinociceptive effects of the essential oil from C.
cordiifolius (CcEO).
Chemical analysis by gas chromatography-mass spectrometry revealed 1,8-cineole (25.09%) and α-phellandrene (15.43%) as major constituents.
Antinociceptive activity was evaluated using murine models of chemically induced pain (writhing induced by acetic acid, formalin, capsaicin, and glutamate tests).
Opioid and central nervous systems (CNS) involvement were also investigated.
Regarding antinociceptive activity, CcEO (50 and 100 mg/kg) reduced the number of writhing responses induced by acetic acid and decreased the licking times in both phases of the formalin test.
CcEO also was evaluated in capsaicin- and glutamate-induced nociception.
While no effect was observed in the capsaicin test, CcEO (100 mg/kg) was effective in the glutamate test.
Naloxone, an opioid antagonist, did not affect the antinociceptive activity of CcEO in writhing test.
In conclusion, the antinociceptive effect of CcEO could be explained, at least in part, by inhibition of the glutamatergic system.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Nogueira, Lenise de Morais& da Silva, Monalisa Ribeiro& Santos, Simone Maria dos& de Albuquerque, Julianna Ferreira Cavalcanti& Ferraz, Igor Cavalcanti& Albuquerque, Thaíse Torres de…[et al.]. 2015. Antinociceptive Effect of the Essential Oil Obtained from the Leaves of Croton cordiifolius Baill. (Euphorbiaceae) in Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1063393
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Nogueira, Lenise de Morais…[et al.]. Antinociceptive Effect of the Essential Oil Obtained from the Leaves of Croton cordiifolius Baill. (Euphorbiaceae) in Mice. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1063393
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Nogueira, Lenise de Morais& da Silva, Monalisa Ribeiro& Santos, Simone Maria dos& de Albuquerque, Julianna Ferreira Cavalcanti& Ferraz, Igor Cavalcanti& Albuquerque, Thaíse Torres de…[et al.]. Antinociceptive Effect of the Essential Oil Obtained from the Leaves of Croton cordiifolius Baill. (Euphorbiaceae) in Mice. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1063393
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1063393
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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